Abstract:It is confirmed that the Resina Draconis has an anti-radiation effect. In this paper, the Lewis lung carcinoma mice model is established on the C57/BL mice by injecting the Lewis lung carcinoma cell in the right auxillary of the mice. The mice are irradiated by the 4 Gy γ-radiation and treated with the Resina Draconis. Then the tumor growth and metastasis as well as the blood index are examined to study the effect of the Resina Draconis on the efficacy of radiotherapy for the Lewis lung carcinoma mice. The results show that the Resina Draconis has no obvious effect on the tumor weight, the tumor volume and the tumor metastasis. But the Resina Draconis has a significant protective effect on the blood platelet for the radiotherapy-treated Lewis lung carcinoma mice. Therefore, it might be concluded that the Resina Draconis can be used for the radiotherapy treatment of cancer.
戴荣继, 余博文, 王冉, 代胜平, 陈艳, 林凡凯, 孟薇薇, 邓玉林. 龙血竭对Lewis肺癌小鼠放疗模型的辅助治疗效果[J]. 科技导报, 2015, 33(18): 68-71.
DAI Rongji, YU Bowen, WANG Ran, DAI Shengping, CHEN Yan, LIN Fankai, MENG Weiwei, DENG Yulin. Effect of Resina Draconis on the efficacy of radiotherapy to Lewis lung carcinoma mice. Science & Technology Review, 2015, 33(18): 68-71.
[1] Wang J, Yu M H, Xiao L L, et al. Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro[J]. Oncology Reports, 2013, 30(2): 917-924.
[2] Wang L J, Liu X J, Guan Y, et al. Optimal timing of radiotherapy with alternating/sequential radio-chemotherapy for limited-stage small cell lung cancer[J]. Asian Pacific Journal of Cancer Prevention, 2014, 15 (14): 5697-5699.
[3] Selz J, LeScodan R, Menard J, et al. Indication of radiotherapy after neoadjuvant chemotherapy in breast cancer[J]. Cancer Radiotherapie, 2014, 18(3): 229-234.
[4] Zhu Y D, Zhang P, Yu H P, et al. Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis[J]. Journal of Natural Products, 2007, 70(10):1570-1577.
[5] Mothana R A A, Mentel R, Reiss C, et al. Phytochemical screening and antiviral activity of some medicinal plants from the Island Soqotra[J]. Phytotherapy Research, 2006, 20(4): 298-302.
[6] Vesela D, Marel R, Ubik K, et al. Dracophane, a metacyclophane derivative from the resin of Dracaena cinnabari Balf[J]. Phytochemistry, 2002, 61(8): 967-970.
[7] Gupta D, Bleakley B, Gupta R K. Dragon's blood: Botany, chemistry and therapeutic uses[J]. Journal of Ethnopharmacology, 2008, 115(3): 361-380.
[8] 刘芳, 戴荣继, 吕芳, 等. 龙血竭总酚提取物化学成分的分离鉴定[J]. 北京理工大学学报, 2014, 34(1): 102-105. Liu Fang, Dai Rongji, Lü Fang, et al. Isolation and structural identification of compounds from total phenols estract of dargon's blood [J]. Transactions of Beijing Institute of Technology, 2014, 34(1): 102-105.
[9] Ran Y Y, Wang R, Hasan M, et al. Radioprotective effects of dragon's blood and its extracts on radiation-induced myelosuppressive mice[J]. Journal of Ethnopharmacology, 2014, 154(3): 624-634.
[10] Ran Y Y, Wang R, Gao Q, et al. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice[J]. Journal of Radiation Research, 2014, 55(4): 699-706.
[11] Ran Y Y, Wang R, Lin F K, et al. Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells[J]. Physica Medica-european Journal of Medical Physics, 2014, 30(4): 427-431.
[12] Lin Y. Dietary supplementation with curcumin enhances metastaticgrowth of Lewis lung carcinoma in mice[J]. International Journal of Cancer, 2013, 132(2): 269-275.
[13] Li D G, Lu L, Zhang J L, et al. Mitigating the effects of xuebijing injection on hematopoietic cell injury induced by total body irradiation with gamma rays by decreasing reactive oxygen species levels[J]. International Journal of Molecular Sciences, 2014, 15(6): 10541-10553.