Effects of insulinoma resection on islet function, serum hormone and CEA levels
MA Xingpo1,2, NIU Min2, SHEN Jinfu2, ZHANG Qiu1
1. Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;
2. Department of Endocrinology, Fuyang People's Hospital, Fuyang 236000, China
Abstract:Changes in serum hormones, carcinoembryonic antigen (CEA) and islet function index levels before and after insulinoma resection are explored. It is found that from day 1 to day 5 after the operation, the patients' homeostasis model assessment-β (HOMA-β) and insulin sensitivity index (ISI) decrease, insulin resistance index (homeostasis model assessment of insulin resistance, HOMA-IR) and blood glucose levels increase, and CEA level increases first and then decreases. The difference is statistically significant (P<0.05). Compared with day 5 after the operation, patients' HOMA-β and ISI levels increase and HOMA-IR levels decrease from day 10 to day 15 after the operation; insulin levels are 14.16±3.06 μU/L, but significantly lower than those before the operation, the blood glucose level drops to 4.62±0.31 mmol/L, which is significantly higher than 2.12±0.59 mmol/L before the operation. There is no significant change in CEA index and the difference is not statistically significant (P>0.05). There is significant correlation between CEA level and various indicators. Pancreatic islet function indicators, serum hormones and CEA levels can cause an abnormal decrease in insulin levels and a sharp increase in blood glucose levels within a short period of time after surgery, which can be used as prognostic indicators.
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