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Feasibility Study of Carbonyl Iron Powder as a Novel Mediator of Arterial Embolization Hyperthermia for Liver Cancer Treatment |
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Abstract: This paper explores the feasibility of carbonyl iron powder to be used as a novel mediator of arterial embolization hyperthermia. Based on in vitro morphology study, the particle diameter distribution of the carbonyl iron powder is measured by laser light scattering with particle size analyzer, and the morphology of these particles is observed by Scanning Electron Microscopy(SEM). Mouse fibroblast L-929 cells are cultured in the medium of extraction of carbonyl iron powder. The cytotoxicity is graded by the generally accepted standard. In in vitro heating experiment, different doses of carbonyl iron powder/Lipiodol suspension are heated in an alternating magnetic field. The influences of the doses of suspension and the magnetic field are observed. As animal models, the normal New Zealand half lop rabbits are treated with arterial embolization hyperthermia by using the suspension. Cytotoxicity study demonstrates that Carbonyl Iron Powder (CIP) shows good biocompatibility. The heating profiles of in vitro and in vivo experiments reveal that CIP possesses the ideal property with inductive heating characteristics under the alternative magnetic field and it does not affect the normal temperature of animal models. These findings suggest that CIP is a very promising mediator candidate of arterial embolization hyperthermia for clinical applications.
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Received: 14 April 2010
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