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Preparation and Characterization of Polyethyleneimine Modified Fe3O4 Magnetic Nanoparticles |
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Abstract: The orthogonality test was used to obtain the optimal technology for preparing magnetic nanoparticles coated with covalently-bound biofunctional polyethyleneimine (PEI). We propose PEI-Fe3O4 magnetic nanoparticles as a mediator for hyperthermia in vitro and in vivo. The processing of polyethyleneimine modified Fe3O4 magnetic nanoparticles includes the preparation of magnetic Fe3O4 nanoparticles and then integrating the Polyethyleneimine modified magnetic nanoparticles and Fe3O4. Examination and characterization of the polyethyleneimine modified Fe3O4 magnetic nanoparticles were performed using simple methods. Simple analyses of the factors affecting the preparation of polyethyleneimine modified Fe3O4 magnetic nanoparticles were made, and the optimal technology was obtained after the optimization of these factors by means of a L8(27) orthogonality test. The optimal technological conditions obtained were: use of ammonium chloride to keep the pH in the range of 9.3~9.7; the ferric ions must be kept in the ratio Fe2+/Fe3+=1:1.75; a polyethyleneimine solution with mass-fractional of 20% should be used; a mechanical stirring at of 1400r/min should be maintained; and the reaction temperature should be held at 85℃. The resulting polyethyleneimine modified Fe3O4 magnetic nanoparticles were characterized using Fourier transform infrared spectroscopy, transmission electron microscope, X-ray diffraction, vibrating sample Magnetometry, and Thermogravimetric Analysis. The results show that the particles have a spinel structure, are superparamagnetic, and have good performance Their diameter is about 9.4nm, their magnetic concentration is 82%, and their magnetization is 61.962emu/g. Further investigation is needed to confirm the nanoparticles effectiveness as a mediator for hyperthermia in vitro and in vivo.
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Received: 19 April 2010
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