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Metabonomic Studies on Abnormal Savda Syndrome Patients with Neoplasm Using NMR Spectroscopy |
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Abstract: This paper studies metabonomic changes in plasma of Abnormal Savda syndrome patients with neoplasm based on the theory of Traditional Uighur Medicine. A 1H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed on plasma samples obtained from 223 cases of Abnormal Savda syndrome patients with neoplasm and 50 healthy volunteers, and the data were analyzed using Orthogonal Partial Least-Squares
Discriminant Analysis (OPLS-DA). The results show that in plasma of Abnormal Savda syndrome patients with neoplasm, a wide range of amino acids including Leucine, Alanin, Citruline, Tyrosine, Histidine, Glycine, Methionine, Isoleucine, Valine, Acetylcysteine see a significant decrease(P<0.05) and Glycoprotein, Glutamine, Myo-inositol, Lactic acid, Choline Creatine are also decreased (P<0.05). Formic acid, Acetone, Acetic acid, Acetoacetate, Pyruvate, β-Hydrocxy butyrate, Carnitine, Malonic acid are increased as compared with healthy plasma metabolites (P<0.05). It is concluded that in Abnormal Savda syndrome patients with neoplasm, lipid metabolism-related metabolites are increased, with abnormal amino acid metabolism, cytoplasm membrane defects, oxidative damage due to abnormal antioxidation ability. These findings indicate that the Abnormal Savda syndrome may be accompanied with imbalance of endocrine dysfunction of the body, low immune function, structural changes of protein, carbohydrates, nucleic acid, biological macromolecules, membrane lipid peroxidation, membrane protein and receptor variability, which will be followed by various diseases such as neoplasm.
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Received: 20 April 2009
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