The central region connects the east to the west, the south to the north, and plays an important role in the coordinated development of regions across China. This paper first analyzes the characteristics of the central region in terms of national coordinated development from the national level, and then explains the situation that the coordinated development of the central region faces the "four no" problems, such as uncoordinated development between the north and the south, mismatching of economic agglomeration and population agglomeration, underdevelopment of special types of regions, and imperfect coordinated development mechanism. Finally, to tackle the "four no" problems, combined with the characteristics of coordinated development, this paper puts forward some policy suggestions from four aspects: constructing the spatial pattern of regional coordinated development, deepening the reform of the registered residence system in megacities, improving the development policy system for special types of regions, and improving the mechanism for coordinated regional development.