Experimental Study of Effects of Uygur Medicine Xipayi Kuijie'an on Colon Mucosa Apoptosis and the Mechanism of Treating Ulcerative Colitis
IMINJAN Mubarak1,2, YUNUS Kurax3, HIZBILLA Mawlanjan2, HUPUR Halmurat4, LI Yuanjian1
1. Xiang Ya Medical Institute, Central South University, Changsha 410013,China;2. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China;3. College of Basic Medicine, Xinjiang Medical University, Urumqi 830011, China;4. Traditional Uygur Medicine Department, Xinjiang Medical University, Urumqi 830011, China
Abstract:To investigate the efficiency and the mechanism of the Uygur herb medicine Turkish Gall aqueous(KJA) in treating Ulcerative colitis and Colon cancer, we detect in vitro HT-29 cell apoptotic rate intervened by different concentrations of KJA and in vivo DNCB plus acetic acid induced UC's model rat apoptotic rate, morphological, pathological CMDI grading score changes of colon mucosa after being intervened by KJA. The results were compared between the normal group, the model control group, the mesalazine positive control group, the mesalazine plus KJA group, the KJA gavage group and the KJA enema group in three courses of treatment. It is demonstrated that the KJA would possibly have a therapeutic function in vitro to Colon cancer HT-29 cell by inducing cell apoptosis rate and in vivo to UC in rat by reducing colon mucosa morphological, pathological abnormal damages and inducing the apoptosis rate of colon mucosa damaged cells.
木巴拉克·伊明江;库热西·玉努斯;买吾兰江·依孜布拉;哈木拉提·吾甫尔;李元健. 维药西帕依溃结安灌肠剂对细胞凋亡的影响及其抗溃疡性结肠炎机理[J]. , 2011, 29(32): 29-35.
IMINJAN Mubarak;YUNUS Kurax;HIZBILLA Mawlanjan;HUPUR Halmurat;LI Yuanjian. Experimental Study of Effects of Uygur Medicine Xipayi Kuijie'an on Colon Mucosa Apoptosis and the Mechanism of Treating Ulcerative Colitis. , 2011, 29(32): 29-35.