癫痫的发病机制研究进展

doi:10.3981/j.issn.1000-7857.2017.04.009

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摘要癫痫是神经系统的常见疾病之一，其发病机制十分复杂，目前尚未完全阐明。近年来，关于癫痫发病机制的研究表明，癫痫的发生与离子通道、神经递质、突触连接、神经血管单元、神经胶质细胞等均存在密切联系。为深入理解癫痫发病机制，为诊断、预防与治疗癫痫提供必要的理论依据，本文从离子通道、神经突触传递与连接、神经血管单元完整性、神经胶质细胞4个方面对癫痫发生机制的研究进展做一综述。

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关键词 ：癫痫, 发病机制, 离子通道, 神经递质, 突触连接

Abstract：The epilepsy is one of the most common diseases of the nervous system, and its pathogenesis is very complex. In recent years, studies of the pathogenesis of the epilepsy have shown that the occurrence of the epilepsy is closely related to the ion channels, the neurotransmitters, the synaptic connections, the neurovascular units and the glial cells. This review focuses on the pathogenesis of the epilepsy and the theoretical basis for the diagnosis, the prevention and the treatment of the epilepsy.

Key words： epilepsy pathogenesis ion channel neurotransmitter synaptic connection

收稿日期: 2016-12-28

基金资助:国家自然科学基金项目（81271312）；首都卫生发展科研专项（首发2016-1-2011）；北京市医院管理局临床新技术创新项目（XMLX201401）

通讯作者: 王群(通信作者),主任医师,研究方向为癫痫基础与临床、脑血管病基础,电子信箱:wangq@ccmu.edu.cn E-mail: wangq@ccmu.edu.cn

作者简介: 杨华俊,博士研究生,研究方向为癫痫基础与临床,电子信箱:doctor_yanghuajun@126.com

引用本文:

杨华俊, 郭安臣, 王群. 癫痫的发病机制研究进展[J]. 科技导报, 2017, 35(4): 54-59.
YANG Huajun, GUO Anchen, WANG Qun. Advances in pathogenesis of epilepsy. Science & Technology Review, 2017, 35(4): 54-59.

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http://www.kjdb.org/CN/10.3981/j.issn.1000-7857.2017.04.009 或 http://www.kjdb.org/CN/Y2017/V35/I4/54

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