Abstract:Disease is key factor restricting sustainable development of fisheries. No fish species with enhanced disease-resistance are available in China.The development of fish functional genomics and molecular marker techniques provides chance for screening functional genes or molecular markers related to disease-resistance. Molecular breeding techniques such as transgenesis, gene marker-assisted selection breeding and molecular marker-assisted selection breeding are potential approaches to developing new strains with enhanced disease-resistance in aquaculture, which should be strengthened in China. The aim of this paper is to provide a survey on the progress in the field of fish disease resistance-related functional genes and molecular breeding.