Abstract:In the information economy era, it's important to enforce e-business transformation for all traditional industries. After a review on the business model change and the value-net theory under the e-business environment, we constructed a model of key business process of the medicine industry, and combining the analysis of industry characters, product characters, channel characters and customer characters of the medicine industry, we got 6 e-business models that fit the medicine industry based on the value-net. Through the value-net model, medicine enterprises can analyze, choose and implement e-business model based on it.