T细胞抑制性受体及其免疫调节作用

doi:10.3981/j.issn.1000-7857.2015.18.014

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摘要 T 淋巴细胞在免疫系统中发挥细胞免疫、免疫调节等功能。然而, T 细胞的过度激活会导致疾病(如哮喘、系统性红斑狼疮等)的发生, 抑制T 细胞的过度激活是免疫治疗的重要研究方向。T 细胞抑制性受体可通过与其配体结合调控T 细胞增殖或功能发挥, 并在过敏性疾病、移植排斥等治疗中作为治疗靶点。因此, 进一步解析T 细胞抑制性受体的三维结构、配体-受体复合物组分及其下信游号通路将有助于免疫治疗的发展。本综述总结了GITR、CTLA-4、BTLA、PD-1、LAIR-1、TIM-3、TIGIT 等T 细胞抑制性受体的生理生化特性、与其配体结合后对T 细胞免疫功能的调节以及抗体药物的研究进展。

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	王帅威
	罗雪瑞
	李扬扬
	林芳
	李丹
	袁晓君
	李斌

关键词 ： T 细胞, 抑制性受体, 免疫调节

Abstract：T lymphocytes play a fundamental role in cellular immune and immune regulation in immune system. However, the overactivation of T cells may induce many diseases including asthma, systemic lupus-erythematosus. It is crucial to control the T cell over-activation in the immunotherapy field. The inhibitory receptors of T cells can regulate proliferation and function of T cells by contacting with their ligands. Latest studies have indicated that T cell inhibitory receptors targeting therapy can attenuate the symptoms of diseases and graft rejection. Intensive study on the regulation of T cells would provide effective strategies for preventing and treating immune diseases.

Key words： T lymphocyte inhibitory receptor immune regulation

收稿日期: 2015-03-11

ZTFLH:

R392.11

基金资助:国家重点基础研究计划(973计划)项目(2014CB541803,2014CB541903);国家自然科学基金项目(31200647,81330072,31370863,31170825,81271835,31200646,81302532,31300711);上海市学术委员会基础研究重大重点项目(14JC1406100);国家科技重大专项(2012ZX10002007-003)

通讯作者: 李斌,教授,研究方向为分子免疫,电子信箱:binli@sibs.ac.cn E-mail: binli@sibs.ac.cn

作者简介: 王帅威,硕士研究生,研究方向为分子免疫,电子信箱:swwang@ips.ac.cnv

引用本文:

王帅威, 罗雪瑞, 李扬扬, 林芳, 李丹, 袁晓君, 李斌. T细胞抑制性受体及其免疫调节作用[J]. 科技导报, 2015, 33(18): 84-90.
WANG Shuaiwei, LUO Xuerui, LI Yangyang, LIN Fang, LI Dan, YUAN Xiaojun, LI Bin. Immune regulatory function of T cell-inhibitory receptors. Science & Technology Review, 2015, 33(18): 84-90.

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http://www.kjdb.org/CN/10.3981/j.issn.1000-7857.2015.18.014 或 http://www.kjdb.org/CN/Y2015/V33/I18/84

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