阻断精神分裂症的发病进程——精神病高危人群的识别和干预

doi:10.3981/j.issn.1000-7857.2017.04.006

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摘要以精神分裂症为主要代表的重性精神障碍的诊疗一直是临床医学中较为棘手的问题。近年来，越来越多的科研团队开始将这一群体的临床和基础研究提前到了精神病高危综合征阶段，这在很大程度上促进了精神病早期干预技术和理念的发展。本文综述了精神病人群的临床和行为学特征、生物学标记和有效干预手段等相关研究最新进展，探讨了精神病早期识别和干预技术的未来发展方向。

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	张天宏
	王继军
	王传跃

关键词 ：精神病前驱期, 临床高危综合征, 超高危人群, 生物学标记, 早期干预

Abstract：The diagnosis and the treatment of the severe mental disorder, represented by schizophrenia, are difficult as a clinical medicine problem. In recent years, the clinical and basic researches are focused on the prodromal psychosis, with the development of techniques and concepts in psychotic early intervention to a great extent. In this paper, the latest progress of the clinical and behavioral characteristics, the biological markers and the effective intervention for individuals at high risk of psychosis are reviewed, and the future development directions of related researches in early identification and intervention techniques for psychosis are pointed out.

Key words： prodromal psychosis clinical high risk ultra high risk biomarker early intervention

收稿日期: 2016-12-27

基金资助:国家自然科学基金项目（81671329，81671332，81471365，81361120403）；上海市科委医学引导类项目（14411961400）；上海交通大学医工交叉项目（YG2014MS40）；上海市优秀学术带头人计划项目（16XD1402400）；北京市科技计划项目（Z161100002616017）；北京脑重大疾病研究院重点项目（PXM2015_014226_000051）

通讯作者: 王传跃(通信作者),主任医师,研究方向为精神病的生物学标记,电子信箱:wang.cy@163.net E-mail: wang.cy@163.net

作者简介: 张天宏,主治医师,研究方向为精神病早期识别和干预,电子信箱:zhang_tianhong@126.com

引用本文:

张天宏, 王继军, 王传跃. 阻断精神分裂症的发病进程——精神病高危人群的识别和干预[J]. 科技导报, 2017, 35(4): 40-44.
ZHANG Tianhong, WANG Jijun, WANG Chuanyue. Preventing the process of schizophrenia onset: Identification and intervention for individuals at high risk of psychosis. Science & Technology Review, 2017, 35(4): 40-44.

链接本文:

http://www.kjdb.org/CN/10.3981/j.issn.1000-7857.2017.04.006 或 http://www.kjdb.org/CN/Y2017/V35/I4/40

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