Functional design of selenium nanomedicine and its application progress in tumor precision treatment
ZHANG Zehang1, LIU Ting1, LI Haiwei2, SANG Chengcheng2, CHEN Yikang2, CHEN Tianfeng1
1. College of Chemistry and Materials Science of Jinan University, Guangzhou 510632, China;
2. Guangdong Jinan Established Selenium Source Nano Technology Research Institute Co., Ltd., Guangzhou 510535, China
Abstract:Nanoselenium, as a new type of elemental selenium, has higher bioavailability, stronger biological activity and lower toxicity than organic selenium and inorganic selenium, and simultaneously has anti-oxidant and anti-tumor effects. This article mainly summarizes the application progress of selenium nanoparticles (SeNPs) in biomedicine, such as chemotherapy, radiotherapy, radio-chemotherapy and other clinical drugs to enhance the sensitization by SeNPs; the functionalization and targeted modification of SeNPs to enhance the anti-tumor effect; Se-nanomaterials in anti-tumor application; the toxicology of SeNPs; and the description of the industrialization research of SeNPs production. The review provides a guidance and support for the future nanoselenium production, study and research integration system.
[1] Siegel R L, Miller K D, Jemal A. Cancer statistics[J]. CA:A Cancer Journal for Clinicians, 2016, 66(1):7-30.
[2] Peer D, Karp J M, Hong S, et al. Nanocarriers as an emerging platform for cancer therapy[J]. Nature Nanotechnology, 2007, 2:751-760.
[3] Koley P, Pramanik A. Nanostructures from single amino acid-based molecules:Stability, fibrillation, encapsulation, and fabrication of silver nanoparticles[J]. Advanced Functional Materials, 2011, 21(21):4126-4136.
[4] 李傲瑞, 乔新星, 赵飞飞, 等. 硒与人体健康关系研究进展[J]. 绿色科技, 2020(12):121-122.
[5] Xie Q, Zhou Y, Lan G, et al. Sensitization of cancer cells to radiation by selenadiazole derivatives by regulation of ROS-mediated DNA damage and ERK and AKT pathways[J]. Biochemical and Biophysical Research Communications, 2014, 449(1):88-93.
[6] Hu Y, Liu T, Li J, et al. Selenium nanoparticles as new strategy to potentiate γδ T cell anti-tumor cytotoxicity through upregulation of tubulin-α acetylation[J]. Biomaterials, 2019, 222:119397.
[7] Huang Y, Fu Y, Li M, et al. Chirality-driven transportation and oxidation prevention by chiral selenium nanoparticles[J]. Angewandte Chemie, 2020, 59(11):4436-4444.
[8] Huang J, Huang W, Zhang Z, et al. Highly uniform synthesis of selenium nanoparticles with EGFR targeting and tumor microenvironment-responsive ability for simultaneous diagnosis and therapy of nasopharyngeal carcinoma[J]. ACS Applied Materials & Interfaces, 2019, 11(12):11177-11193.
[9] Zheng L, Huang X, Lin X, et al. Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy[J]. Biomaterials, 2019(216):119220.
[10] 郭芷君, 徐峰. 化学治疗所致恶心呕吐分类与药物治疗的研究进展[J]. 中国药业, 2020, 29(22):1-6.
[11] Fang X, Li Ce, Zheng L, et al. Dual-targeted selenium nanoparticles for synergistic photothermal therapy and chemotherapy of tumors[J]. Chemistry-An Asian Journal, 2018, 13(8):996-1004.
[12] Wang Y, Liu X, Deng G, et al. Se@SiO2- FA- CuS nanocomposites for targeted delivery of DOX and nano selenium in synergistic combination of chemo-photothermal therapy[J]. Nanoscale, 2018, 10(6):2866-2875.
[13] Deng G, Zhu T, Zhou L, et al. Bovine serum albuminloaded nano-selenium/ICG nanoparticles for highly effective chemo-photothermal combination therapy[J]. RSC Advances, 2017, 7(49):30717-30724.
[14] Britten R A, Warenius H M, Carraway A V, et al. Differential modulation of radiosensitivity following induction of cis-platinum resistance in radiation-sensitive and radiation-resistant human tumor cells[J]. Radiation Oncology Investigations, 1994, 2:25-31.
[15] Shi J, Kantoff P W, Wooster R, et al. Cancer nanomedicine:Progress, challenges and opportunities[J]. Nature Reviews Cancer, 2017, 17(1):20.
[16] Yu B, Liu T, Du Y, et al. X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy[J]. Colloids and Surfaces B:Biointerfaces, 2016(139):180-189.
[17] Chen F, Zhang XH, H u X D, et al. The effects of combined selenium nanoparticles and radiation therapy on breast cancer cells in vitro[J]. Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46:937-948.
[18] Du J, Gu Z, Yan L, et al. Poly (Vinylpyrollidone) -and selenocysteine-modified Bi2Se3 nanoparticles enhance radiotherapy efficacy in tumors and promote radioprotection in normal tissues[J]. Advanced Materials, 2017, 29(34):1701268.
[19] Yang Y, Xie Q, Zhao Z, et al. Functionalized selenium nanosystem as radiation sensitizer of 125I seeds for precise cancer therapy[J]. ACS Applied Materials & Interfaces, 2017, 9(31):25857-25869.
[20] Chang Y, He L, Li Z, et al. Designing core-shell gold and selenium nanocomposites for cancer radiochemotherapy[J]. ACS Nano, 2017, 11(5):4848-4858.
[21] Zhang H, Sun Q, Tong L, et al. Synergistic combination of PEGylated selenium nanoparticles and X-ray-induced radiotherapy for enhanced anticancer effect in human lung carcinoma[J]. Biomedicine & Pharmacotherapy, 2018, 107:1135-1141.
[22] Yang F, Tang Q, Zhong X, et al. Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles[J]. International Journal of Nanomedicine, 2012, 7:835-844.
[23] Wu H L, Li X L, Liu W, et al. Surface decoration of selenium nanoparticles by mushroom polysaccharides-protein complexes to achieve enhanced cellular uptake and antiproliferative activity[J]. Journal Materials Chemitry, 2012, 22(19):9602-9610.
[24] Yu B, Zhang Y B, Zheng W J, et al. Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles[J]. Inorganic Chemistry, 2012, 51(16):8956-8963.
[25] Zhang Y B, Li X L, Huang Z, et al. Enhancement of cell permeabilization apoptosis-inducing activity of selenium nanoparticles by ATP surface decoration[J]. Nanomedicine:Nanotechnology, Biology and Medicine, 2013, 9(1):74-84.
[26] Zheng S Y, Li X L, Zhang Y B, et al. PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction[J]. International Journal of Nanomedicine, 2012, 7:3939-3949.
[27] Nie T Q, Wu H L, Wong K H, et al. Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis[J]. Journal of Materials Chemistry B, 2016, 4(13):2351-2358.
[28] Huang G N, Liu Z M, He L Z, et al. Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity[J]. Biomaterials Science, 2018, 6(9):2508-2517.
[29] Yu S M, Luk K H, Cheung S T, et al. Polysaccharideprotein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic[J]. Journal of Materials Chemistry B, 2018, 6(32):5215-5219.
[30] Li Y H, Li X L, Zheng W J, et al. Functionalized selenium nanoparticles with nephroprotective activity, the important roles of ROS-mediated signaling pathways[J]. Journal of Materials Chemistry B, 2013, 1(46):6365-6372.
[31] Huang Y Y, He L Z, Liu W, et al. Selective cellular uptake and induction of apoptosis of cancer-targeted selenium nanoparticles[J]. Biomaterials, 2013, 34(29):7106-7016.
[32] Liu T, Zeng L L, Jiang W T, et al. Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells. Nanomedicine[J]. Nanotechnology, Biology and Medicine, 2015, 11(4):947-958.
[33] Fang X Y, Wu X L, Li C E, et al. Targeting selenium nanoparticles combined with baicalin to treat HBV-infected liver cancer[J]. RSC Advances, 2017, 7(14):8178-8185.
[34] Zeng L L, Chen J J, Ji S B, et al. Construction of a cancer-targeted nanosystem as a payload of iron complexes to reverse cancer multidrug resistance[J]. Journal of Materials Chemistry B, 2015, 3:4345-4354.
[35] Liu T, Lai L H, Song Z H, et al. A sequentially triggered nanosystem for precise drug delivery and simultaneous inhibition of cancer growth, migration, and invasion[J]. Advanced Functional Materials, 2016, 26(43):7775-7790.
[36] Jiang W T, Fu Y T, Yang F, et al. Gracilaria iemaneiformis polysaccharide as integrin-targeting surface decorator of selenium nanoparticles to achieve enhanced anticancer efficacy[J]. ACS Applied Materials & Interfaces, 2014, 6(16):13738-13748.
[37] Weis S M, Cheresh D A. Tumor angiogenesis:Molecular pathways and therapeutic targets[J]. Nature Medicine, 2011, 17(11):1359-1370.
[38] Huang J, Huang W, Zhang Z, et al. Highly uniform synthesis of selenium nanoparticles with EGFR targeting and tumor microenvironment-responsive ability for simultaneous diagnosis and therapy of nasopharyngeal carcinoma[J]. ACS Applied Materials & Interfaces, 2019, 11(12):11177-11193.
[39] Yoon D J, Kwan B H, Chao F C, et al. Intratumoral therapy of glioblastoma multiforme using genetically engineered transferrin for drug delivery[J]. Cancer Research, 2010, 70(11):4520-4527.
[40] Wang J, Tian S M, Petros R A, et al. The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies[J]. Journal American Chemistry Society, 2010, 132(32):11306-11313.
[41] Kalli K R, Oberg A L, Keeney G L, et al. Folate receptor alpha as a tumor target in epithelial ovarian cancer[J]. Gynecologic Oncology, 2008, 108(3):619-626.
[42] Lu Y J, Low P S. Folate-mediated delivery of macromolecular anticancer therapeutic agents[J]. Advanced Drug Delivery Reviews, 2012, 64(1):342-352.
[43] Gschwind A, Fischer O M, Ullrich A. Timeline-The discovery of receptor tyrosine kinases:Targets for cancer therapy[J]. Nature Reviews Cancer, 2004, 4(5):361-370.
[44] Arteaga C L, Sliwkowski M X, Osborne C K, et al. Treatment of HER2-positive breast cancer:Current status and future perspectives[J]. Nature Reviews Clinical Oncology, 2012, 9(1):16-32.
[45] Fu X Y, Yang Y H, Li X L, et al. RGD peptide-conjugated selenium nanoparticles:Antiangiogenesis by suppressing VEGF-VEGFR2-ERK/AKT pathway[J]. Nanomedicine:Nanotechnology, Biology and Medicine, 2016, 12(6):1627-1639.
[46] Liu C, Fu Y T, Li C E, et al. Phycocyanin-functionalized selenium nanoparticles reverse palmitic acid-induced pancreatic beta cell apoptosis by enhancing cellular uptake and blocking reactive oxygen species (ROS)-mediated mitochondria dysfunction[J]. Journal of Agricultural and Food Chemistry, 2017, 65(22):4405-4413.
[47] Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy[J]. Journal of Clinical Oncology, 2002, 20(suppl 18):1-13.
[48] Liu T, Shi C, Duan L, et al. A highly hemocompatible erythrocyte membrane-coated ultrasmall selenium nanosystem for simultaneous cancer radiosensitization and precise antiangiogenesis[J]. Journal of Materials Chemistry B, 2018, 6(29):4756-4764.
[49] Yu B, Zhou Y, Song M F, et al. Synthesis of selenium nanoparticles with mesoporous silica drug-carrier shell for programmed responsive tumor targeted synergistic therapy[J]. RSC Advances, 2016, 6(3):2171-2175.
[50] Bi X L, Pohl N, Dong H L, et al. Selenium and sulindac are synergistic to inhibit intestinal tumorigenesis in Apc/p21 mice[J]. Journal of Hematology & Oncology 2013, 6(1):1-7.
[51] Liu X J, Wang Y Y, Yu Q Y, et al. Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy[J]. Colloids and Surfaces B:Biointerfaces, 2018, 166(1):161-169.
[52] Wang Y F, Wang J L, Hao H, et al. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles[J]. ACS Nano, 2016, 10(11):9927-9937.
[53] Wang D H, Ge N J, Qian S, et al. Selenium doped NiTi layered double hydroxide (Ni-Ti LDH) films with selective inhibition effect to cancer cells and bacteria[J]. RSC Advances, 2015(5):106848-106859.
[54] Cremonini E, Zonaro E, Donini M, et al. Biogenic selenium nanoparticles:Characterization, antimicrobial activity and effects on human dendritic cells and fibroblasts[J]. Microbial Biotechnology, 2016, 9(6):758-771.
[55] Tran P A, Webster T J. Selenium nanoparticles inhibit Staphylococcus aureus growth[J]. International Journal of Nanomedicine, 2011(6):1553.
[56] Bandari M, Alsadat M, Asadpour L, et al. Antibacterial effect of synthetized selenium nanoparticles and ampicillin-selenium nanoparticles against clinical isolates of methicillin resistant Staphylococcus aureus[J]. Iranian Journal of Medical Microbiology, 2018, 11:184-191.
[57] Srivastava N, Mukhopadhyay M. Green synthesis and structural characterization of selenium nanoparticles and assessment of their antimicrobial property[J]. Bioprocess and Biosystems Engineering, 2015, 38(9):1723-1730.
[58] Tran P A, Webster T J. Antimicrobial selenium nanoparticle coatings on polymeric medical devices[J]. Nanotechnology, 2013, 24(15):155101.
[59] Bartů něk V, Junková J, Šuman J, et al. Preparation of amorphous antimicrobial selenium nanoparticles stabilized by odor suppressing surfactant polysorbate 20[J]. Materials Letters, 2015, 152(1):207-209.
[60] Khiralla G M, El-Deeb B A. Antimicrobial and antibiofilm effects of selenium nanoparticles on some foodborne pathogens[J]. LWT-Food Science and Technology, 2015, 63(2):1001-1007.
[61] Rana J V S. Synthesis of selenium nanoparticles using Allium sativumextract and analysis of their antimicrobial property against gram positive bacteria[J]. The Pharma Innovation, 2018, 7:262-266.
[62] Huang T, Holden J A, Heath D E, et al. Engineering highly effective antimicrobial selenium nanoparticles through control of particle size[J]. Nanoscale, 2019, 11(31):14937-14951.
[63] Misra S, Boylan M, Selvam A, et al. Redox-active selenium compounds-from toxicity and cell death to cancer treatment[J]. Nutrients, 2015, 7(5):3536-3556.
[64] Zhao Z N, Gao P, You Y Y, et al. Cancer-targeting functionalization of selenium-containing ruthenium conjugate with tumor microenvironment-responsive property to enhance theranostic effects[J]. Chemistry-A European Journal, 2018, 24(13):3289-3298.
[65] Liu C, Lai H, Chen T. Boosting natural killer cell-based cancer immunotherapy with selenocystine/transforming growth factor-beta inhibitor-encapsulated nanoemulsion[J]. ACS Nano, 2020, 14:11067-11082.
[66] Liu Z J, Fu X, Huang W, et al. Photodynamic effect and mechanism study of selenium-enriched phycocyanin from Spirulina platensis against liver tumours[J]. Journal of Photochemistry and Photobiology B:Biology, 2018, 180:89-97.
[67] Liu T, Xu L, He L, et al. Selenium nanoparticles regulates selenoprotein to boost cytokine-induced killer cells-based cancer immunotherapy[J]. Nano Today, 2020, 35:100975.
[68] Nair D, Radestad E, Khalkar P, et al. Methylseleninic acid sensitizes ovarian cancer cells to T-cell mediated killing by decreasing PDL1 and VEGF levels[J]. Frontiers in Oncology, 2018, 8:407.
[69] 霍佳桃, 文海若, 吕建军, 等. 药物毒理学研究中体外替代试验研究现状及展望[J]. 药物评价研究, 2018, 41(12):2133-2141.
[70] Zhang Z H, Du Y X, Liu T, et al. Systematic acute and subchronic toxicity evaluation of polysaccharide-protein complex functionalized selenium nanoparticles with anticancer potency[J]. Biomaterials Science, 2019, 7(12):5112-5123.