Impact of Savda Granule on the Ability of Memory and Antioxidation for APP/PS1 Double Transgenic Mice
UPUR Halmurat1, DANG Ming1, AIZEZI Renaguli1, WUSHOUER Palidan2, KURBAN Abdukadir1, AMAT Nurmuhammat1
1. Traditional Uighur Medicine Institute, Xinjiang Medical University, Urumqi 830011, China;2. Department of Psychosomatic, the Affiliated Traditional Chinese Medicine Hospital, Xinjiang Medical University, Urumqi 830000, China
Abstract：In order to study the effect of savda granule on memory and antioxidation ability for APP/PS1 double transgenic mice, a number of three-month-old APP/PS1 double transgenic mice were randomly divided into five groups. Meanwhile, the mice with negative control were served as a control group. There were eight mice in each group and all of them were intragastrically administered for six months. Then the learning and memory ability of mice were detected by Morris water maze test. The activities of glutathione peroxidase-(GSH-Px) and superoxide in the brain tissue were measured with spectrophotometer. Comparing with the control group, APP/PS1 double transgenic mice significantly prolong the latency for searching the hidden platform in the directional swimming test, and decrease the time spent on swimming in the target quadrant with the probe test. Comparing with APP/PS1 double transgenic mice, savda granule is able to dose-dependently shorten the latency for searching the hidden platform in the directional swimming test, and increase the time spent on swimming in the target quadrant with the probe test. The activities of GSH-Px and SOD decrease in APP/PS1 double transgenic mice, while in the groups with savda granule treatment, the activities of GSH-Px and SOD raise, and there is significant difference comparing with Alzheimer's Disease (AD) model group. Nine-month-old APP/PS1 double transgenic mice present imitated learning and memory dysfunction with the reduction of antioxidation ability; savda granule is able to ameliorate the impaired memory function for the mice with AD and improve their antioxidation ability.