Relationship Between the Signal Transduction Pathway and the Disorder of Neuro-endocrine-immunity Network in Abnormal Savda Hilit
HUANG Jingjing1, LI Chunyan1, YUNUSI Kurexi1, YUNUSI Ayiguli2, MAIMAITI Palidan1, WUBU Nuerbiya3, LIU Wenxian4, UFUER Hamulati4
1. Basic College, Xinjiang Medical University, Urumqi 830011, China;2. Pharmacy, the Second Affiliated Hospital, Xinjiang Medical University, Urumqi 830063, China;3. Urumqi Center for Disease Control and Prevention, Urumqi 830002, China;4. Uyghur Medical College, Xinjiang Medical University, Urumqi 830011, China
Abstract:In order to study the relationship between the signal transduction pathway and the disorder of the neuro-endocrine-immunity network in abnormal Savda Hilit, the blood samples of the abnormal Savda Hilit group and the non-abnormal Savda Hilit group (abnormal Kan Hilit, abnormal Belhem Hilit, abnormal Safra Hilit) were collected. After separating the white blood cell and extracting the RNA, the Affymetrix gene expression microarray technology was applied to detect the gene expression of the two groups. Then the differentially expressed genes were selected and a bioinformatic analysis was made by using the CapitalBio Molecule Annotation System (MAS) to find the genes related to the signal transduction pathway. The result of chip shows that 75 genes are up-regulated in the abnormal Savda Hilit group comparing with the non-abnormal Savda Hilit group. The bioinformatic analysis shows that 12 genes are concentrated in the signal transduction pathways of the biological process, involved in the MAPK, Toll-like receptor, the Wnt signal transduction pathway. These findings indicate that the abnormal activation of the MAPK, Toll-like receptor, the Wnt signal transduction pathway may be related to the disorder of the neuro-endocrine-immunity network in the abnormal Savda Hilit group.
黄静静;李春燕;库热西·玉努斯;阿衣古丽·玉努斯;帕丽旦·麦麦提;努尔比亚·吾布;刘文先;哈木拉提·吾甫尔. 信号转导通路与异常黑胆质证NEI网络功能紊乱的关系[J]. , 2013, 31(26): 64-67.
HUANG Jingjing;LI Chunyan;YUNUSI Kurexi;YUNUSI Ayiguli;MAIMAITI Palidan;WUBU Nuerbiya;LIU Wenxian;UFUER Hamulati. Relationship Between the Signal Transduction Pathway and the Disorder of Neuro-endocrine-immunity Network in Abnormal Savda Hilit. , 2013, 31(26): 64-67.