不同溶剂及配比对碳纳米管辅助薄层色谱拆分盐酸普萘洛尔的影响

doi:10.3981/j.issn.1000-7857.2014.009

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摘要以羟丙基-β-环糊精、甲基-β-环糊精为手性固定相，氧化多壁碳纳米管为拆分辅助吸附添加剂，采用薄层色谱法拆分了盐酸普萘洛尔对映体。优化得到了最佳展开剂条件，并对展开剂中是否添加冰醋酸进行了比较。当以羟丙基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/异丁醇（体积比为9:1）混合溶剂中添加体积分数为2%的冰醋酸。当以甲基-β-环糊精/氧化多壁碳纳米管为固定相制备薄层色谱板，用于拆分盐酸普萘洛尔时，最佳的展开剂条件为：乙腈/正丁醇（体积比为1：1）混合溶剂中添加体积分数为2%的冰醋酸。

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	姚元香
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关键词 ：多壁碳纳米管, β-环糊精衍生物, 手性分离, 薄层色谱

Abstract：This paper evaluates the hydroxypropyl-β-cyclodextrin or methyl-β-cyclodextrin-based chiral stationary phase, with oxidized multi-walled carbon nanotubes as additional adsorbing materials, for the chiral separation of propranolol hydrochloride enantiomers. The compositions of the developing solvent (acetonitrile/various alcohols), with/without acetic acid, are optimized. The optimal solvent system of acetonitrile/iso-butanol 9/1 (V/V) containing 2% acetic acid (in volume) for hydroxypropyl-β-cyclodextrin/ oxidized multi-walled carbon nanotubes impregnated thin-layer chromatography, and the optimal solvent system of acetonitrile/n-butanol 1/1 (V/V) containing 2% acetic acid (in volume) for methyl-β-cyclodextrin/oxidized multi-walled carbon nanotubes impregnated thinlayer chromatography are obtained.

Key words： carbon nanotubes β-cyclodextrin derivatives chiral separation thin-layer chromatography

收稿日期: 2013-07-29

ZTFLH:

O656.9

基金资助:国家自然科学基金项目（21201181）；有色金属资源化学教育部重点实验室开放基金项目（2012-KF-04）；湖南省科技计划项目（2012RS4007）

通讯作者: 彭志光，讲师，研究方向为纳米材料制备及应用，电子信箱：zhgpeng@csu.edu.cn E-mail: zhgpeng@csu.edu.cn

作者简介: 姚元香，工程师，研究方向为新材料制备及应用、分离分析新技术等，电子信箱：yuanxyao@sina.com

引用本文:

姚元香, 刘金云, 谭新良, 彭志光, 金杭丹. 不同溶剂及配比对碳纳米管辅助薄层色谱拆分盐酸普萘洛尔的影响[J]. 科技导报, 2014, 32(1): 65-69.
YAO Yuanxiang, LIU Jinyun, TAN Xinliang, PENG Zhiguang, JIN Hangdan. Effects of Various Solvent Systems and the Ratios on Thin-Layer Chromatographic Enantio-separation of Propranolol Hydrochloride. journal1, 2014, 32(1): 65-69.

链接本文:

http://www.kjdb.org/CN/10.3981/j.issn.1000-7857.2014.009 或 http://www.kjdb.org/CN/Y2014/V32/I1/65

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