Abstract：As a fresh growth on technology and economy, new solutions of telematics, navigation, internet and entertainment while driving based on In-Vehicle Information System (IVIS) was applied widely in automobile industry recently. The process of automobile-informationization has been accelerated gradually. However, based on Multi-Resource Theory, the application of IVIS during driving in forms of display check and text input distracted drivers visually in certain degrees, which caused threats to driving safety by competing with major driving tasks on visual, cognitive and other resources. Previous research found that the glance frequency and duration from using IVIS related to crashes and traffic dangers directly, meanwhile, decreased driver's ability on detecting key road incidents and controlling vehicles. Thus the safety design of IVIS, which focused on human-machine interactive method and driver's behavioral character, was very important. General methodologies of such research include field test, simulation test and simple laboratory test.