Abstract：The gene polymorphism of Angiotensin-Converting Enzyme (ACE) gene, Nitric Oxide Synthase (eNOS) gene, coagulation Factor VII (FVII) gene and Intercellular Cell Adhesion Molecules-1 (ICAM-1) in Uighur patients with Coronary Heart Disease (CHD) in Xinjiang are studied in this paper. The four types of genes related to CHD are compared to each other by using polymerized chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 124 cases of CHD Uighur patients and 50 healthy subjects as verified by diagnosis. The results show that there are no significant differences in genotype distribution and allele frequencies of ACE gene, FVII gene, ICAM-1 gene in Uighur patients with CHD when compared to healthy subjects (P>0.05). There are significant differences in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD when compared to healthy subjects (P<0.05). There is no correlation in genotype distribution and allele frequencies of ACE gene, FVII gene, ICAM-1 gene in Uighur patients with CHD in Xinjiang. Significant correlation is discovered in genotype distribution and allele frequencies of eNOS gene in Uighur patients with CHD in Xinjiang
2009, Vol. 27 
