Abstract：To observe the effect of Pueraria lobata (Willd.) Ohwi on relief of alcohol toxicity by animal experiments, female NIH mice were ovariectomized and randomly divided into 5 groups. The animal models of acute alcoholism were duplicated by force-feeding them with liquor "er guo tou". The influence of aqueous extract of Pueraria lobata (Willd.) Ohwion on the alcohol concentration in blood within 0.5~3 hours was studied by methods of biochemistry. The alcohol concentration in blood took the highest value in 0.5~1.5 hours. Compared to the model group, the alcohol concentration in blood for the group of aqueous extract of Pueraria lobata (Willd.) Ohwi is decreased in 0.5~3 hours; the activity of ADH in the liver is increased in 2~3 hours (P＞0.05), while it is significantly increased in the first 0.5~1 hours (P＜0.05). The aqueous extract of Pueraria lobata (Willd.) Ohwi could reduce the alcohol concentration in blood of animals after being fed with alcohol and increase the activity of ADH. It relieves alcohol toxicity and prevents drunkenness by restraining the absorption of alcohol in the gastrointestinal tract and promoting the metabolism of alcohol in the liver.
2009, Vol. 27 
