角膜生物力学特性研究进展

张海霞; 张迪; 秦晓; 孙太凤; 李林

doi:10.3981/j.issn.1000-7857.2018.13.003

PDF(1927 KB)

科技导报 ›› 2018, Vol. 36 ›› Issue (13) : 23-29. DOI: 10.3981/j.issn.1000-7857.2018.13.003

专题论文

角膜生物力学特性研究进展

作者信息 -

1. 首都医科大学生物医学工程学院, 北京 100069;
2. 首都医科大学临床生物力学应用基础研究北京市重点实验室, 北京 100069

作者简介:

张海霞,副教授,研究方向为眼生物力学,电子信箱:zhanghx@ccmu.edu.cn

Progress of research on corneal biomechanical properties

Author information -

1, School of Biomedical Engineering, Capital Medical University, Beijing 100069, China;
2. Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China

摘要

角膜的光学功能与其形态结构紧密相联，角膜形态的异常可导致近视、远视、圆锥角膜等眼部疾病。细致研究角膜的力学特性，建立有临床用途的生物力学模型已成为一个重要研究领域。本文以首都医科大学眼生物力学研究团队的研究工作为基础，综述在角膜力学特性研究中的实验测试方法和本构参数获取方法等方面的进展。

Abstract

The optical function of cornea is closely associated with its morphological structure. Abnormal corneal morphology can lead to myopia, hyperopia and keratoconus. It is an important subject to study the corneal mechanical characteristics. The result will improve the understanding of corneal surgery and predict postoperative through establishing the biomechanical model with clinical application. In this paper, based on the research work of the ophthalmic biomechanics team of Capital Medical University, we review the corneal biomechanical testing methods and the corneal constitutive parameter research.

导出引用

张海霞, 张迪, 秦晓, 孙太凤, 李林. 角膜生物力学特性研究进展[J]. 科技导报, 2018, 36(13): 23-29 https://doi.org/10.3981/j.issn.1000-7857.2018.13.003

ZHANG Haixia, ZHANG Di, QIN Xiao, SUN Taifeng, LI Lin. Progress of research on corneal biomechanical properties[J]. Science & Technology Review, 2018, 36(13): 23-29 https://doi.org/10.3981/j.issn.1000-7857.2018.13.003

参考文献

[1] Roberts C. The cornea is not a piece of plastic[J]. Journal of Refractive Surgery, 2000, 16(4):407-413.
[2] Su P, Yang Y, Xiao J, et al. Corneal hyper-viscoelastic model:Derivations, experiments, and simulations[J]. Acta of Bioengi-neering & Biomechanics, 2015, 17(2):73-84.
[3] 瞿佳. 我国眼视光学领域的学术发展方向[J]. 中华眼科杂志,2015, 51(1):122-125. Qu Jia. The status quo and expectation of optometry research in China[J]. Chinese Journal of Ophthalmology, 2015, 51(1):122-125.
[4] 谢祥勇. 儿童近视的中西医防治进展[J]. 广西中医学院学报, 2012, 15(2):80-82. Xie Xiangyong. Progress in the prevention and treatment of children's myopia[J]. Journal of Guangxi tranditional Chinese Medical University, 2012, 15(2):80-82.
[5] 冯元祯. 生物力学:活组织的力学特性[M]. 长沙:湖南科学技术出版社, 1986. Feng Y C. Biomechanics:Mechanics properties of living tissues[M]. Changsha:Hunan Science and Technology Press, 1986.
[6] Zeng Y, Yang J, Huang K, et al. A comparison of biomechani-cal properties between human and porcine cornea[J]. Journal of Biomechanics, 2001, 34:533-537.
[7] Nguyen T D, Jones R E, Boyce B L. A nonlinear anisotropic viscoelastic model for the tensile behavior of the corneal stroma[J]. Journal of Biomechanical Engineering, 2008, 130(4):397-405.
[8] Elsheikh A, Alhasso D. Mechanical anisotropy of porcine cor-nea and correlation with stromal microstructure[J]. Experimen-tal Eye Research, 2009, 88(6):1084-1091.
[9] 朱怀亮, 谢严, 梁思辉, 等. 活性猪眼角膜的各向异性生物力学行为研究[J]. 中国生物医学工程学报, 2009, 28(1):153-156. Zhu Hailiang, Xie Yan, Liang Sihui, et al. Research on the anisotropy biomechanical behavior of living pig eye cornea[J]. Chinese Journal of Biomedical Engineering, 2009, 28(1):153-156.
[10] 曾衍钧, 任庆华, 徐巽珠, 等. 猪眼角膜的本构方程和应力松弛[J]. 中国生物医学工程学报, 1995, 14(4):360-364. Zeng Jinyan, Ren Qinghua, Xu Xunzhu, et al. Constitutive equation and stress relaxation of pig corneas[J]. Chinese Journal of Biomedical Engineering, 1995, 14(4):360-364.
[11] Boschetti F, Triacca V, Spinelli L, et al. Mechanical character-ization of porcine corneas[J]. Journal of Biomechanical Engi-neering. 2012, 134(3):031003.
[12] 王爱玉, 陈维毅, 贺瑞, 等. 兔眼LASIK术后角膜生物力学特性的实验研究[J]. 生物医学工程杂志, 2009, 26(2):323-326. Wang Aiyu, Chen Weiyi, He Rui, et al. Experimental study on corneal biomechanical properties of rabbit eye after LASIK[J]. Journal of Biomedical Engineering, 2009, 26(2):323-326.
[13] Elsheikh A, Anderson K. Comparative study of corneal strip extensometry and inflation test[J]. Journal of the Royal Soci-ety Interface, 2005, 2(3):177-185.
[14] 谢毅, 樊瑜波, 邓应平, 等. 兔眼准分子激光原位角膜磨镶术后角膜扩张的研究[J]. 生物医学工程研究, 2008, 27(1):19-22. Xie Yi, Fan Yubo, Deng Yingping, et al. The research of Post-LASIK keratectasia in rabbits' eyes after LASIK surgery[J]. Journal of Biomedical Engineering, 2008, 27(1):19-22.
[15] 陈维毅, 王晓君, 刘春生, 等. 兔眼球生物力学特性的实验研究[J]. 医用生物力学, 2009, 24(增刊1):8. Chen Weiyi, Wang Xiaojun, Liu Chunsheng, et al. Experimental study on the biomechanical properties of rabbit eyes[J]. Journal of Medical Biomechanics, 2009, 24(Suppl 1):8.
[16] Elsheikh A, Alhasso D, Rama P. Biomechanical properties of human and porcine corneas[J]. Experimental Eye Research, 2008, 86(5):783-790.
[17] 倪寿翔, 郁继国, 包芳军, 等. 近视LASIK术后角膜生物力学参数变化的相关性[J]. 国际眼科杂志, 2010, 10(12):2305-2307. Ni Shouxiang, Yu Jiguo, Bao Fangjun, et al. Changes of corneal biomechanical parameters after myopia laser in situ keratomileusis[J]. International Journal of Ophthalmology, 2010, 10(12):2305-2307.
[18] Kotecha A, Elsheikh A, Roberts C R, et al. Corneal thick-ness-and age-related biomechanical properties of the cornea measured with the ocular response analyzer[J]. Investigative Ophthalmology & Visual Science, 2006, 47(12):5337-5347.
[19] Tanter M, Touboul D, Bercoff J, et al. High resolution quanti-tative imaging of cornea elasticity using supersonic shear im-aging[J]. IEEE Transactions on Medical Imaging, 2009, 28(12):1881-1893.
[20] Bercoff J, Tanter M, Fink M. Supersonic shear imaging:A new technique for soft tissue elasticity mapping[J]. IEEE Transactions on Ultrasonics, Ferroelectronics, and Frequency Control, 2004, 51(4):396-409.
[21] Khan M A, 郝蕴, 李贝, 等. 眼反应分析仪在角膜屈光手术中的应用[J]. 中国医疗设备, 2017, 31(3):76-79. Khan M A, Hao Yun, Li Bei, et al. Application of ocular response analyzer in corneal refractive surgery[J]. China Medical Devices, 2017, 31(3):76-79.
[22] Piñero D P, Natividad A. Corneal biomechanics:A review[J]. Clinical and Experimental Optometry, 2015, 98(2):107-116.
[23] 王平, 姜德咏. 青少年儿童角膜内皮细胞随年龄变化规律分析[J]. 国际眼科杂志, 2004, 4(3):438-440. Wang Ping, Jiang Deyong. Changes in corneal endothelium of children and youngsters[J]. International Journal of Ophthalmology, 2004, 4(3):438-440.
[24] Zhang H, Qian X, Cao X, et al. Age-related variations of rab-bit corneal geometrical and clinical biomechanical parameters[J]. BioMed Research International, 2017, 2017(3), doi:10.1155/2017/3684971.
[25] 张海霞, 李林, 张昆亚, 等. 兔眼角膜生物力学特性的年龄相关性[J]. 医用生物力学, 2014, 29(3):271-275. Zhang Haixia, Li lin, Zhang Kunya, et al. Age-related changes in biomechanical properties of rabbit corneas[J]. Journal of Medical Biomechanics, 2014, 29(3):271-275.
[26] Li L, Qian X, Wang H, et al. Power type strain energy func-tion model and prediction of the anisotropic mechanical prop-erties of skin using uniaxial extension data[J]. Medical & Bio-logical Engineering & Computing, 2013, 51(10):1147-1156.
[27] Holzapfel G A, Gasser T C, Ogden R W. A new constitutive framework for arterial wall mechanics and a comparative study of material models[J]. Journal of Elasticity, 2012, 61(1/3):1-48.
[28] 孙太凤, 王慧枝, 穆晶, 等. 基于整体角膜膨胀实验对兔眼角膜参数的确定[J]. 北京生物医学工程, 2016, 35(2):191-197. Sun Taifeng, Wang Huizhi, Mu Jing, et al. Determining the biomechanical properties of rabbit cornea with inflation tests[J]. Beijing Biomedical Engineering, 2016, 35(2):191-197.
[29] Zhang D, Sun T, Zhang H, et al, The simulation study on the deformation of rabbit cornea after refractive surgery with dif-ferent cutting thickness[J]. Journal of Mechanics in Medicine and Biology, 2017, 17(8):1750118.
[30] Nguyen T D, Boyce B L. An inverse finite element method for determining the anisotropic properties of the cornea[J]. Biome-chanics & Modeling in Mechanobiology, 2011, 10(3):323-337.
[31] 祝雅利, 陈维毅. LASIK术后眼球受力变形的有限元模拟研究[J]. 太原理工大学学报, 2008, 39(增刊2):257-260. Zhu Yali, Chen Weiyi. The simulation study on the finite element analysis of the eyeball deformation after LASIK[J]. Journal of Taiyuan University of Technology, 2008, 39(Suppl 2):257-260.
[32] 王秀玲, 李爽. 正常与病态眼角膜拉伸力学的特性[J]. 中国组织工程研究与临床康复, 2010, 14(46):8590-8593. Wang Xiuling, Li Shuang. Tensile mechanical properties of normal and pathological corneas[J]. Journal of Clinical Reheabilitative Tissue Enginerring Research, 2010, 14(46):8590-8593.
[33] Li L, Qian X, Yan S, et al. Determination of material parame-ters of the two-dimensional Holzapfel-Weizsäcker type mod-el based on uniaxial extension data of arterial walls[J]. Com-puter Methods in Biomechanics and Biomedical Engineering, 2013, 16(4):358-367.
[34] Li L, Qian X, Yan S, et al. Determination of the material pa-rameters of four-fibre family model based on uniaxial exten-sion data of arterial walls[J]. Computer Methods in Biome-chanics and Biomedical Engineering, 2014, 17(7):695-703.
[35] Li L, Hua L, Zhang H, et al. Differences between pulmonary arterial and aortic material properties[J]. Journal of Mechan-ics in Medicine and Biology, 2015, 15(3):1550019.
[36] Zhang H, Qin X, Li L, et al. Understanding the viscoelastic properties of rabbit cornea based on stress relaxation test and cyclic uniaxial tests[J]. Journal of Mechanics in Medicine and Biology, 2017, 17(7):1740035.
[37] Zhang H, Khan M A, Zhang D, et al. Corneal biomechanical properties after FS-LASIK with residual bed thickness less than 50% of the original corneal thickness[J]. Journal of Oph-thalmology, 2018, 2018(5), doi:10.1155/2018/2752945.