Abstract：Shenzhen is one of the core engine cities in the Guangdong-Hong Kong-Macao Greater Bay Area and the pilot zone for socialism with Chinese characteristics. Demonstrating a new mode of transportation modernization management in megacity and building a multimodal transportation network that effectively supports the construction of global benchmark city are the two strategic choices of Shenzhen. Based on the transportation resource endowment, this paper analyzes the opportunities and challenges of megacity, and puts forward the path of high-quality transportation development with the help of science and technology application and mechanism innovation in megacity. Then, four major directions of building a strong transportation network are formed. This paper also proposes a series of core tasks that need to be broken through. Moreover,this paper explores how to build a strong transportation network which could efficiently support the strategic orientation of the city and transportation service, as well as help science and technology innovation to be widely applied.