Abstract：The samples of nine cases of panda liver and kidney were collected from the veterinary hospital of Beijing Zoo. The histopathological method was used to observe the pathological lesion of the liver and kidney tissues. The cytochemistry and immunohistochemistric methods were used for detection of the hepatitis virus infection in pandas. The results show that, there are varying degrees of pathological changes in liver and kidney tissues in all samples. The livers see extensive congestion, edema and hemorrhage, and widespread degeneration and atrophy of hepatocytes are observed in some cases. Apart from sporadic necrosis, hepatocytes show multiple-focal necrosis and widespread necrosis. Bile duct proliferation is present in the portal area. The liver interstitium shows inflammatory cell infiltration and fibroplasia. Hemosiderin pigmentation is found in the liver in all cases. Kidney pathological changes consist of extension of the renal glomerulus capsular space, degeneration and necrosis of renal tubular epithelial cells, fibrosis and inflammatory cell infiltration of renal interstitium, and protein cast in the renal tubular. Immunohistochemistry shows that both the positive detectable rates of HBV and HEV are high, however, the extents of the positive reaction are obviously different. Mallory trichromatic staining shows that different levels of proliferation of the fibrous tissue are found in the liver and kidney tissues in the nine cases of pandas. These studies provide evidence that the inflammation reaction prevails in the liver and kidney tissues in the nine cases of pandas and the initiation of the inflammation may be closely related to HBV and HEV.