According to the theory of Uighur traditional medicine, male wistar rats were fed with a diet of cold-nature under cool dry environment, stimulated with chronic and interrupted electric foot shocks to establish abnormal savda syndrome rat model in Uighur medicine in three weeks. DEN was used further to establish hepatocarcinoma carrying abnormal savda disease animal model till the hepatocirrhosis occurred. The alterations of IL-1β, IL-6, TNF-α, ACTH and CORT in serum level were monitored. The results show that compared with the normal group the serum levels of IL-1β, IL-6 and TNF-α in the abnormal savda syndrome model group were increased (for IL-1β, P<0.01; for IL-6 and TNF-α, P<0.001); compared with the model control group the serum levels of IL-6 and TNF-α in the abnormal savda syndrome model group were increased (P<0.01); compared with the normal group the serum levels of ACTH and CORT in the model control group, the abnormal savda disease group and the abnormal savda syndrome model group were all increased, with significant mathematical differences, compared with the model control group the serum level of ACTH in the abnormal savda syndrome model group was significantly increased (P<0.05). These findings indicate that the immune-endocrin network was disordered in hepatocirrhosis phase of hepatocarcinoma carrying abnormal savda model. In the process of pathological changes of hepatic tissue in hepatocarcinoma carrying abnormal savda model, DEN is the main induction agent, and abnormal savda hilit is the accelerative factor. In addition, the abnormal savda, disordered immune-endocrin network and DEN are closely related and stimulated with each other.