Abstract：The suspension is a complex mechanical system, for which it is very difficult to define the optimization function. There are more than one system performance indices for every component of the vehicle, which are interrelated, with complicated impact on the vehicle. From a theoretical viewpoint, the objective function to optimize the suspension system is very difficult to formulate. In this paper, based on the multi-body system dynamics method, the virtual prototyping model of a mini passenger car is built. Considering vehicle handling stability and ride comfort, by using the degree of understeering and the roll rate in the steady circular test and the total RMS acceleration values in the method of random input running test of automotive ride comfort as the evaluation indices, the orthogonal experiment is designed, and the effects of the suspension structure parameters on handling stability and riding such as the suspension rate of the front suspension and the rear suspension, the torsion stiffness of the antiroll bar, the damping ratio of the front and rear suspensions are studied. Then the important factors are found, together with the optimum combination of the simulation-based suspension parameters. The final results provide some guidance and support for the optimization of the suspension parameters.