Abstract：The Uygur medicine Hyssopus officinalis L. on serum Eotaxin-2, Eotaxin-3 and sP-selectin levels of asthma rats is studied for the mechanism of its treatment of asthma. The test rats were randomly divided into normal control group, asthma model group and dexamethasone group and Hyssopus officinalis L. high and low dose group. They were sensitized with OVA, Al(OH)3 and DPT vaccine, and then were challenged with inhalation of aerosolized OVA solution for preparation of asthma model. The levels of serum Eotaxin-2, Eotaxin-3 and sP-selectin were determined with ELISA. The results show that as compared with model group, the number of EOS in BALF of the treatment groups is significantly reduced, and serum levels of Eotaxin-2 are decreased significantly (P<0.05). Compared with Hyssopus officinalis L. low-dose treatment group, the number of EOS in BALF is significantly reduced for the high dose group, and the serum levels of Eotaxin-2 are decreased significantly (P<0.05). The number of EOS in BALF and the serum levels of Eotaxin-2 are closely related (r=0.829). The EOS has a positive relationship with the serum Eotaxin-3 and sP-selectin levels (r=0.635, 0.348), P＜0.05. The serum Eotaxin-2 level has a positive relationship with the Eotaxin-3 sP-selectin levels (r=0.447, 0.362, P＜0.05). It is concluded that Eotaxin-2, Eotaxin-3 and sP-selectin may be in a mutual coordination, to aggravate the inflammatory response of asthma. Hyssopus officinalis L. may inhibit the secretion of Eotaxin-2, reducing the inflammatory response of asthma.