Abstract:To investigate the expressions of IGF-I, OPN and PTEN and their correlation with prognosis in Non-Small Cell Lung Cancer (NSCLC), immunohistochemical staining was used to identify the expression of IGF-I, OPN and PTEN in 61 cases of NSCLC and 30 cases of adjacent non-cancer tissues. In NSCLC cases, the expressions of IGF-I and OPN were higher than those in the adjacent non-cancer tissues (P<0.05). The positive rates of IGF-I were closely correlated with the stage of tumor and lymph node metastasis. The positive rates of OPN were closely correlated with the grade of differentiation, lymph node metastasis and TNM staging. In NSCLC cases, the expression of PTEN was lower than those in the adjacent non-cancer tissues (P<0.05), the positive rates of PTEN was closely correlated with size of tumor, the grade of differentiation and lymph node metastasis (P<0.05). The expression of IGF-Iwas correlated positively with that of OPN (P<0.05). The expression of IGF-I and OPN were correlated negatively with that of PTEN (P<0.05). It is concluded that the expressions of IGF-I, OPN and PTEN are related to the occurrence and progression of NSCLC. And they may serve a valuable index for diagnosing the malignant extent and prognosis of lung cancer