Abstract:The metabonomic differences of plasma between abnormal savda and unsavda syndrome neoplasm are studied in light of the traditional Uighur medicine. Plasma samples were obtained from 80 cases of abnormal savda syndrome neoplasm patients and 160 cases of abnormal unsavda syndrome neoplasm patients. For each sample, the 1H Nuclear Magnetic Resonance (NMR) based metabonomic analysis was performed and the obtained data was analyzed by the Orthogonal Partial Least-Squares Discriminant Analysis (OPLS-DA). The results show that the abnormal savda syndrome neoplasm patients have a lower degree of glucose, Very Low Density Lipoprotein (VLDL), unsaturated lipids, alanine and a higher degree of fatty acid metabolites like acetone, acetoacetate, β-hydrocxy butyrate, isobutyrate; product of glycolysis like lactate, pyruvate; amino acids like leucine, tyrosine, isoleucine, valine, acetylcysteine; another metabolites like myo-inositol,glycoprotein in plasma than the unsavda syndrome neoplasm patients(P<0.05). These findings indicate that the abnormal savda syndrome neoplasm patients have a higher degree of fat mobilization and glycolysis level, their immune function is more seriously damaged and their prognosis may be worse than that of abnormal unsavda syndrome neoplasm patients.