Abstract：For the prognosis of treatment it is important to timely and accurately evaluate the liver fibrosis in a chronic liver disease. The most reliable diagnosis of liver biopsy available has many limitations, such as the inhomogeneity of liver damage would result in sampling errors and some damage will be done to patients. It is difficult to dynamically observe the process of hepatic fibrosis and fibrosis formation. There is also no reliable way to determine the content of collagen in liver. The diagnose of liver fibrosis based only on a rough estimate has a limited applications. In recent years, a number of combined indicators of liver fibrosis were applied to diagnosis and evaluation. Comprehensive index models for hepatic fibrosis non-invasive diagnosis attract much attention. In order to better understand and apply these diagnostic models, this paper reviews the major progress of non-invasive diagnosis, especially, from two aspects: the serological diagnosis and imaging diagnosis. The limitations and development directions of the current non-invasive diagnosis are discussed. Some food for thought is given for the development of new better comprehensive index models.