1. Traditional Uighur Medicine Department, Xinjiang Medical University, Urumqi 830011, China;2. Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
Abstract：The hemorheological and coagulation effects of Abnormal Savda Munziq (ASM), as an herbal preparation used in Traditional Uighur Medicine, on the abnormal savda rat model are investigated. The level of whole blood viscosity, plasma viscosity, whole blood reduced viscosity, erythrocyte aggregation index, deformation index, rigidity index, electrophoresis index, hematocrit, and other indicators were determined by the LBY-N6B instrument. The level of PT, FIB, TT, and APTT were measured by automated blood coagulation analyzer. The results are as follows: (1) Compared with control group, the whole blood viscosity (low, moderate, and higher shear rate), plasma viscosity are significantly higher in the model group (P<0.05); The erythrocyte rigidity index and erythrocyte deformability index decrease significantly (P<0.05); The thrombin time shortens and FIB increases significantly (P<0.01 respectively); The erythrocyte aggregation index difference is not remarkable (P>0.05); (2) Compared with model group, for the medicine intervention group, whole blood viscosity with low shear rate, whole blood viscosity with moderate shear rate, and whole blood reduced viscosity with moderate and higher shear rate are lower than those in the control group and natural recovery group (P<0.05), respectively; The erythrocyte rigidity index and erythrocyte deformability index increase significantly (P<0.05); The thrombin time shorten could be effectively controlled in the medicine intervention group (P<0.01). The result indicates that the ASM could effectively control the blood hyperviscosity and dysfunction of blood coagulation of abnormal savda syndrome rat model.
阿衣努尔·买提斯迪克;吾尔古力·阿卜杜来海提;哈木拉提·吾甫尔;努尔买买提·艾买提;哈力达·木沙;热娜古丽·艾则孜. 维药异常黑胆质成熟剂对异常黑胆质载体大鼠动物模型血液流变学指标的影响[J]. , 2011, 29(27): 31-35.
MAITISIDIKE Ayinuer;ABUDULAIHAITI Wuerguli;UPOR Hamulati;AIMAITI Nuermaimaiti;MUSHA Halida;AIZEZI Renaguli. Hemorheological Effects of Abnormal Savda Munziq, as a Traditional Uighur Medicine, on the Abnormal Savda Rat Model. , 2011, 29(27): 31-35.