Abstract:The better index of air temperature that can be used to distinguish the epidemic area from non-epidemic area of schistosomiasis using Geographic Information System (GIS), and the potential impacts of climate changes on the spatial distribution of schistosomiasis, were studied. The result shows that Oncomelania Hupensis has the possibility to move north if the other conditions that affect the survival of Oncomelania Hupensis meet, with the global climate warming and the carry-out of south-north water transfer project in China. Global climate warming will cause great challenges for the schistosomiasis control and the distribution of the Oncomelania Hupensis in the future.