1. Department of Psychosomatics, the Affiliated Traditional Chinese Medicine Hospital Xinjiang Medical University, Urumqi 830000, China;2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China
Abstract：This paper establishes a rat model of the Alzheimer's disease with abnormal savda syndrome and evaluates the effectiveness of abnormal savda munziq on the disease. A rat model of the abnormal savda syndrome is first established by using the classical method, then β-Amyloid 1-40 is injected into hippocampus to establish the rat model of the Alzheimer's disease with abnormal savda syndrome. A model group is given the abnormal savda munziq, the biological characterizations and the behavioral changes are observed with the Morris water maze test and the step down test, and the learning and memorizing abilities of different model groups are compared. It is found that compared with the normal group, the daily food and water intakes are increased in the abnormal savda syndrome group and the group of the Alzheimer's disease with abnormal savda syndrome(P<0.01), the body weight is decreased in these two groups(P<0.01); the learning and memorizing abilities are weakened in the AD group, the abnormal savda syndrome group and the group of the Alzheimer's disease with abnormal savda syndrome(P<0.05);the biological characterizations, and the learning and memorizing abilities are improved in the group of the Alzheimer's disease with abnormal savda syndrome plus the abnormal savda munziq(P<0.05). Therefore, it is established that the abnormal savda munziq can improve the biological characterization and the learning and memorizing abilities of rats of the Alzheimer's disease with abnormal savda syndrome.
帕丽丹·吾术尔;哈木拉提·吾甫尔;热娜古丽·艾则孜;努尔买买提·艾买提. 异常黑胆质型痴呆证病结合模型建立及方药干预实验[J]. , 2012, 30(33): 50-55.
WUSHOUER Palidan;UPUR Halmurat;AIZEZI Renaguli;AIMAITI Nuermaimaiti. The Rate Model of Alzheimer's Disease with Abnormal Savda Syndrome and the Effectness of the Related Medical Formulas. , 2012, 30(33): 50-55.
2012, Vol. 30 
