作为第3代氟诺酮类合成抗菌药,氧氟沙星的抗菌谱广、抗菌活性强、口服吸收完全、体内分布广、生物利用度高.但氧氟沙星有效抑菌浓度低,对多数致病菌的MIC₉₀在1μg·mL^-1内,因此制备更为安全有效的氧氟沙星缓释制剂十分必要.本文采用微波辅助硝酸氧化法修饰了多壁碳纳米管引入羧基,制备了氧化多壁碳纳米管.在对甲苯磺酸催化下,以聚乙二醇修饰了氧化多壁碳纳米管,制备了分散性能较好的多壁碳纳米管-聚乙二醇复合材料.以多壁碳纳米管-聚乙二醇复合材料为药物载体、氧氟沙星为模型药物,考查了多壁碳纳米管-聚乙二醇复合材料的载药释药性能.研究结果表明：多壁碳纳米管-聚乙二醇复合材料具有较大的载药率,达92.8%;在磷酸缓冲溶液(pH=7.4)中,24h内可持续稳定缓慢释放氧氟沙星.

As the third generation of synthetic flouroquinolone antibacterials, the ofloxacin is a potent antifungal agent with a broad antifungal spectrum, a strong antibacterial activity, the ability of completely oral absorption,a wide distribution in tissue and a high bioavailability. By using the nitric acid to treat multi-walled carbon nanotubes (MWNTs) under the microwave irradiation, the carboxyl groups were introduced onto the MWNTs and the oxidized MWNTs (MWNTs-COOH) were prepared. Catalized by the p-toluenesulfonic acid, the poly(ethylene glycol) modified MWNTs (PEG-g-MWNTs) with good dispersivity were synthesized. The PEG-g-MWNTs composites were used as the drug delivery for drug loading/releasing of the ofloxacin. It is indicated that the PEG-g-MWNTs has a great load rate (92.8%) for the ofloxacin, which can be sustained, controlled and released in the phosphate buffer solution (pH=7.4) in 24h.