为探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与新疆汉族人群乳腺癌的相关性, 按维吾尔医将乳腺癌患者分为4 种体液型, 采用聚合酶链式反应(PCR)技术对新疆汉族139 例乳腺癌患者和72 例正常对照组ACE 基因I/D 多态性进行检测, 比较各组间等位基因和基因型频率分布的差异。结果显示, 异常黏质乳腺癌患者组II 基因型频率(P=0.018)和I 等位基因频率(P=0.004)都显著高于正常对照组;异常黏液质乳腺癌患者组I 等位基因频率显著高于异常黑胆质乳腺癌患者组(P=0.012)。由此得出, ACE 基因I 等位基因和II 基因型可能增加新疆汉族维吾尔医异常黏液质型乳腺癌的发病风险。
This paper investigates the relationship between the polymorphisms of ACE gene and the breast cancer with abnormal Hilit in Chinese Han population in Xinjiang. The breast caner patients are divided into four groups according to body fluids based on the Uighur medicine theory, the polymerase chain reaction technique is employed to detect the genotype and the allele frequencies of the I/D polymorphism in the ACE gene in 124 breast cancer patients with abnormal Hilit and 72 normal control subjects in the Han population in Xinjiang. It is shown that the frequency of the I allele and the II genotype is significantly higher in the breast caner patients with abnormal balgham Hilit than in the control (P=0.004; P=0.018); the frequency of the I allele is significantly higher in the breast caner patients with abnormal balgham Hilit than in the breast caner patients with abnormal black Savda (P=0.012). It is concluded that the I allele and the II genotype in ACE gene may increase the risk of breast cancer with Uighur medicine abnormal balgham Hilit.
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