研究论文

幽门螺杆菌感染对肠道菌群的影响

  • 董红霞 ,
  • 梁浩 ,
  • 闵敏
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  • 1. 中国人民解放军总医院消化科, 北京 100853;
    2. 中国人民解放军307医院消化科, 北京 100071
董红霞,主治医师,研究方向为肠道菌群与疾病的关系,电子信箱:dhongxia20080808@163.com

收稿日期: 2015-01-19

  修回日期: 2015-03-09

  网络出版日期: 2015-05-04

基金资助

国家自然科学基金项目(81300277)

Effect of Helicobacter pylori infection on gut microbiota

  • DONG Hongxia ,
  • LIANG Hao ,
  • MIN Min
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  • 1. Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China;
    2. Department of Gastroenterology, Chinese PLA 307 Hospital, Beijing 100071, China

Received date: 2015-01-19

  Revised date: 2015-03-09

  Online published: 2015-05-04

摘要

为研究幽门螺杆菌(Helicobacter pylori,Hp)感染对肠道菌群的影响,收集Hp 阴性和Hp 感染(阳性)患者的粪便标本,选择Hp 和肠道菌群中具代表性的大肠杆菌O157、乳酸杆菌、肠球菌、双歧杆菌进行PCR 扩增。实验结果表明,Hp 阴性组中未见Hp 表达,与13C 呼气实验结果基本一致;Hp 阴性组中乳酸杆菌、肠球菌、双歧杆菌表达较高,而Hp 感染组中3 者表达较少;Hp 阴性组中未检测到大肠杆菌O157。幽门螺杆菌感染可改变肠道菌群中乳酸杆菌、肠球菌、双歧杆菌等菌落的数量。

本文引用格式

董红霞 , 梁浩 , 闵敏 . 幽门螺杆菌感染对肠道菌群的影响[J]. 科技导报, 2015 , 33(7) : 90 -94 . DOI: 10.3981/j.issn.1000-7857.2015.07.015

Abstract

This paper studies the effect of Helicobacter pylori (Hp) infection on gut microbiota using fresh stool specimens collected from normal persons (Hp negative) and patients with Hp infection. Hp, E. coli O157, Lactobacillus, Enterococcus and Bifidobacterium were amplified by PCR. The expression of Hp was not found in Hp negative group, consistent with the 13C breath test. The expression of Lactobacillus, Enterococcus and Bifidobacterium in Hp negative group was higher than that in Hp infection group. There was no E. coli O157 in Hp negative group. The numbers of Lactobacillus, Enterococcus and Bifidobacterium were changed by Hp infection.

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