研究论文

龙血竭对Lewis肺癌小鼠放疗模型的辅助治疗效果

  • 戴荣继 ,
  • 余博文 ,
  • 王冉 ,
  • 代胜平 ,
  • 陈艳 ,
  • 林凡凯 ,
  • 孟薇薇 ,
  • 邓玉林
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  • 1. 北京理工大学生命学院, 北京 100081;
    2. 北京理工亘元科技有限公司, 北京 100081
戴荣继,教授,研究方向为生物活性物质分离,电子信箱:dairongji@bit.edu.cn。

收稿日期: 2015-04-01

  修回日期: 2015-06-04

  网络出版日期: 2015-10-16

基金资助

国家重大仪器专项(2012YQ040140)

Effect of Resina Draconis on the efficacy of radiotherapy to Lewis lung carcinoma mice

  • DAI Rongji ,
  • YU Bowen ,
  • WANG Ran ,
  • DAI Shengping ,
  • CHEN Yan ,
  • LIN Fankai ,
  • MENG Weiwei ,
  • DENG Yulin
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  • 1. School of Life Science, Beijing Institute of Technology, Beijing 100081, China;
    2. BIT & GY Technologies Co., Ltd., Beijing 100081, China

Received date: 2015-04-01

  Revised date: 2015-06-04

  Online published: 2015-10-16

摘要

龙血竭具有一定的防辐射作用。通过在C57/BL 小鼠右前腋窝皮下注射Lewis 肺癌细胞, 对小鼠进行4 Gy 全身一次性γ辐射建立Lewis 肺癌小鼠放疗模型, 并给予小鼠龙血竭, 进行肿瘤生长、肿瘤转移和血象变化检测, 研究了龙血竭对Lewis 肺癌小鼠放疗模型的血象及肿瘤生长的辅助治疗效果。实验发现, 龙血竭不会促进放疗Lewis 肺癌小鼠的肿瘤生长和转移, 并能够有效保护放疗Lewis 肺癌小鼠的血小板。研究表明, 龙血竭应用于肿瘤的放射治疗可以对辐射引起机体的血象损伤起到保护作用。

本文引用格式

戴荣继 , 余博文 , 王冉 , 代胜平 , 陈艳 , 林凡凯 , 孟薇薇 , 邓玉林 . 龙血竭对Lewis肺癌小鼠放疗模型的辅助治疗效果[J]. 科技导报, 2015 , 33(18) : 68 -71 . DOI: 10.3981/j.issn.1000-7857.2015.18.011

Abstract

It is confirmed that the Resina Draconis has an anti-radiation effect. In this paper, the Lewis lung carcinoma mice model is established on the C57/BL mice by injecting the Lewis lung carcinoma cell in the right auxillary of the mice. The mice are irradiated by the 4 Gy γ-radiation and treated with the Resina Draconis. Then the tumor growth and metastasis as well as the blood index are examined to study the effect of the Resina Draconis on the efficacy of radiotherapy for the Lewis lung carcinoma mice. The results show that the Resina Draconis has no obvious effect on the tumor weight, the tumor volume and the tumor metastasis. But the Resina Draconis has a significant protective effect on the blood platelet for the radiotherapy-treated Lewis lung carcinoma mice. Therefore, it might be concluded that the Resina Draconis can be used for the radiotherapy treatment of cancer.

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