龙血竭具有一定的防辐射作用。通过在C57/BL 小鼠右前腋窝皮下注射Lewis 肺癌细胞, 对小鼠进行4 Gy 全身一次性γ辐射建立Lewis 肺癌小鼠放疗模型, 并给予小鼠龙血竭, 进行肿瘤生长、肿瘤转移和血象变化检测, 研究了龙血竭对Lewis 肺癌小鼠放疗模型的血象及肿瘤生长的辅助治疗效果。实验发现, 龙血竭不会促进放疗Lewis 肺癌小鼠的肿瘤生长和转移, 并能够有效保护放疗Lewis 肺癌小鼠的血小板。研究表明, 龙血竭应用于肿瘤的放射治疗可以对辐射引起机体的血象损伤起到保护作用。
It is confirmed that the Resina Draconis has an anti-radiation effect. In this paper, the Lewis lung carcinoma mice model is established on the C57/BL mice by injecting the Lewis lung carcinoma cell in the right auxillary of the mice. The mice are irradiated by the 4 Gy γ-radiation and treated with the Resina Draconis. Then the tumor growth and metastasis as well as the blood index are examined to study the effect of the Resina Draconis on the efficacy of radiotherapy for the Lewis lung carcinoma mice. The results show that the Resina Draconis has no obvious effect on the tumor weight, the tumor volume and the tumor metastasis. But the Resina Draconis has a significant protective effect on the blood platelet for the radiotherapy-treated Lewis lung carcinoma mice. Therefore, it might be concluded that the Resina Draconis can be used for the radiotherapy treatment of cancer.
[1] Wang J, Yu M H, Xiao L L, et al. Radiosensitizing effect of oleanolic acid on tumor cells through the inhibition of GSH synthesis in vitro[J]. Oncology Reports, 2013, 30(2): 917-924.
[2] Wang L J, Liu X J, Guan Y, et al. Optimal timing of radiotherapy with alternating/sequential radio-chemotherapy for limited-stage small cell lung cancer[J]. Asian Pacific Journal of Cancer Prevention, 2014, 15 (14): 5697-5699.
[3] Selz J, LeScodan R, Menard J, et al. Indication of radiotherapy after neoadjuvant chemotherapy in breast cancer[J]. Cancer Radiotherapie, 2014, 18(3): 229-234.
[4] Zhu Y D, Zhang P, Yu H P, et al. Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis[J]. Journal of Natural Products, 2007, 70(10):1570-1577.
[5] Mothana R A A, Mentel R, Reiss C, et al. Phytochemical screening and antiviral activity of some medicinal plants from the Island Soqotra[J]. Phytotherapy Research, 2006, 20(4): 298-302.
[6] Vesela D, Marel R, Ubik K, et al. Dracophane, a metacyclophane derivative from the resin of Dracaena cinnabari Balf[J]. Phytochemistry, 2002, 61(8): 967-970.
[7] Gupta D, Bleakley B, Gupta R K. Dragon's blood: Botany, chemistry and therapeutic uses[J]. Journal of Ethnopharmacology, 2008, 115(3): 361-380.
[8] 刘芳, 戴荣继, 吕芳, 等. 龙血竭总酚提取物化学成分的分离鉴定[J]. 北京理工大学学报, 2014, 34(1): 102-105. Liu Fang, Dai Rongji, Lü Fang, et al. Isolation and structural identification of compounds from total phenols estract of dargon's blood [J]. Transactions of Beijing Institute of Technology, 2014, 34(1): 102-105.
[9] Ran Y Y, Wang R, Hasan M, et al. Radioprotective effects of dragon's blood and its extracts on radiation-induced myelosuppressive mice[J]. Journal of Ethnopharmacology, 2014, 154(3): 624-634.
[10] Ran Y Y, Wang R, Gao Q, et al. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice[J]. Journal of Radiation Research, 2014, 55(4): 699-706.
[11] Ran Y Y, Wang R, Lin F K, et al. Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells[J]. Physica Medica-european Journal of Medical Physics, 2014, 30(4): 427-431.
[12] Lin Y. Dietary supplementation with curcumin enhances metastaticgrowth of Lewis lung carcinoma in mice[J]. International Journal of Cancer, 2013, 132(2): 269-275.
[13] Li D G, Lu L, Zhang J L, et al. Mitigating the effects of xuebijing injection on hematopoietic cell injury induced by total body irradiation with gamma rays by decreasing reactive oxygen species levels[J]. International Journal of Molecular Sciences, 2014, 15(6): 10541-10553.
