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2015年生命科学热点回眸

  • 吴晓丽
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  • 1. 《中国学术期刊文摘》编辑部, 北京 100081;
    2. 《科技导报》编辑部, 北京 100081

网络出版日期: 2016-02-04

摘要

2015 年无疑在生命科学历史画卷上写下了浓墨重彩的一笔。站在新起点,本文盘点2015 年生命科学领域取得的重大研究进展,回顾基因组编辑技术、图谱、结构生物学、干细胞、埃博拉、艾滋病、癌症、糖尿病等研究领域的热点突破。

本文引用格式

吴晓丽 . 2015年生命科学热点回眸[J]. 科技导报, 2016 , 34(1) : 23 -35 . DOI: 10.3981/j.issn.1000-7857.2016.01.001

参考文献

[1] 林小春. 2015年《科学》十大突破出炉:基因剪刀居首[EB/OL]. 2015-12-19. http://www.chinanews.com/gj/2015/12-19/7678245.shtml.
[2] Liang P, Xu Y, Zhang X, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes[J]. Protein & Cell, 2015, 6(5): 363-372.
[3] 我国科学家基因编辑人类胚胎引争议[EB/OL]. 2015-04-24. http://news.bioon.com/article/6668501.html.
[4] 2015年基因编辑领域重磅级研究TOP10[EB/OL]. 2015-12-29. http://news.bioon.com/article/6676437.html.
[5] Ledford H. Alternative CRISPR system could improve genome editing: Smaller enzyme may make process simpler and more exact[J]. Nature, 2015, 526 (7571). doi:10.1038/nature.2015.18432.
[6] Slaymaker I M, Gao L, Zetsche B, et al. Rationally engineered Cas9 nucleases with improved specificity[J]. Science, 2016, 351(6268): 84-88.
[7] 孙学军. 基因编辑技术再获新突破[EB/OL]. 2015-09-30. http://blog.sciencenet.cn/blog-41174-924435.html.
[8] Zetsche B, Zetsche B, Gootenberg J S, et al. Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system[J]. Cell, 2015, 163(3): 759-771.
[9] Zou Q, Wang X, Liu Y, et al. Generation of gene-target dogs using CRISPR/Cas9 system[J]. Journal of Molecular Cell Biology, 2015, doi: 10.1093/jmcb/ mjv061.
[10] 朱汉斌, 黄博纯. 建立世界首个基因敲除狗模型[EB/OL]. 2015-11-03. http://news.sciencenet.cn/htmlpaper/20151131455753637675.shtm?id=37675.
[11] 科学家成功精确改造了人类T细胞基因组[EB/OL]. 2015-08-04. http://www.wokeji.com/jiankang/rw/201508/t20150804_1508863.shtml.
[12] Schumann K, Lin, S, Boyer, E, et al. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins[J]. PNAS, 2015, 112(33): 10437-10442.
[13] 赵熙熙. 基因编辑技术有望治愈肌肉萎缩症[EB/OL]. 2016-01-04. http://news.sciencenet.cn/htmlpaper/2016141451763038324.shtm?id=38324.
[14] Nelson C E, Hakim C H, Ousterout D G, et al. In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy[J]. Science, 2015, doi: 10.1126/science.aad5143.
[15] 房琳琳. 基因编辑技术可干预"埃及伊蚊"肆虐[EB/OL]. 2015-04-04. http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2015-04/01/content_298526.htm?div=-1.
[16] Kistler K E, Vosshall L B, Matthews B J. Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti[J]. Cell Report, 2015, 11(1): 51-60.
[17] 盘点2015:十大生命科学图谱[EB/OL]. 2015-12-31. http://www.ebiotrade.com/newsf/2015-12/20151230123252185.htm.
[18] 最大表观基因组图谱问世有助人类理解疾病成因[EB/OL]. 2015-02-21. http://news.163.com/15/0221/13/AIVVIV4800014AEE.html.
[19] 何嫱. Nature重大成果:最全面的人类器官表观基因组图谱[EB/OL]. 2015-06-03. http://www.biodiscover.com/news/research/119329.html.
[20] Schultz M D, He Y, Whitaker J W, et al. Human body epigenome maps reveal noncanonical DNA methylation variation[J]. Nature, 2015, 523(7559): 212-216.
[21] GTEx Consortium. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans[J]. Science, 2015, 348(6235): 648-660.
[22] Melé M, Ferreira P G, Reverter F, et al. The human transcriptome across tissues and individuals[J]. Science, 2015, 348(6235): 660-665.
[23] Rivas M A, Pirinen M, Conrad D F, et al. Effect of predicted protein-truncating genetic variants on the human transcriptome[J]. Science, 2015, 348 (6235): 666-669.
[24] 施一公团队首次捕获真核细胞剪接体三维结构[EB/OL]. 2015-08-24. http://news.xinhuanet.com/hr/2015-08/24/c_128158927.htm.
[25] 施一公教授研究组在《科学》发表两篇论文报道剪接体的三维结构并阐述RNA剪接的分子结构基础[EB/OL]. 2015-08-21. http://www.tsinghua.edu. cn/publish/news/4205/2015/20150821054238312366972/20150821054238312366972_.html.
[26] Yan C, Hang J, Wan R, et al. Structure of a yeast spliceosome at 3.6-angstrom resolution[J]. Science, 2015, 349(6253): 1182-1191.
[27] Hang J, Wan R, Yan C, et al. Structural basis of pre-mRNA splicing[J]. Science, 2015, 349(6253): 1191-1198.
[28] 吴晶晶. 我国诱导多能干细胞机理研究获得突破性进展[EB/OL]. 2010-06-18. http://news.xinhuanet.com/2010-06/18/c_12235785.htm.
[29] 新方法,干细胞立变骨细胞[EB/OL]. 2015-11-18. http://news.bioon.com/article/6674916.html.
[30] Sen B, Xie, Z, Uzer G, et al. Intranuclear actin regulates osteogenesis[J]. Stem Cells, 2015, 33(10): 3065-3076.
[31] Cell:科学家发现提高造血干细胞移植效率新方法[EB/OL]. 2015-06-18. http://www.bioon.com/tm/TissueEngineering/612498.shtml.
[32] Mantel C R, O'Leary H A, Chitteti B R, et al. Enhancing hematopoietic stem cell transplantation efficacy by mitigating oxygen shock[J]. Cell, 2015, 161 (17): 1553-1565.
[33] Nature:干细胞一关键结构可决定干细胞命运[EB/OL]. 2015-07-06. http://www.bioon.com/3g/id/6670885/.
[34] Inaba M, Buszczak M, Yamashit Y M, et al. Nanotubes mediate niche-stem-cell signalling in the Drosophila testis[J]. Nature, 2015, 523(7560): 329-332.
[35] Nature:终于找到你!肝脏干细胞来源揭秘[EB/OL]. 2015-08-06. http://www.bioon.com/3g/id/6671952/.
[36] Wang B, Zhao L, Fish M, et al. Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver[J]. Nature, 2015, 524(7564): 180-185.
[37] Nature医学颠覆性文章:杜氏肌营养不良其实是干细胞病[EB/OL]. 2015-11-22. http://www.bioon.com/3g/id/6675167/.
[38] Dumont N A, Wang Y, von Maltzahn J, et al. Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division[J]. Nature Medicine, 2015, 21: 1455-1463.
[39] Zhang W, Li J, Suzuk K, et al. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging[J]. Science, 2015, 348 (6239): 1160-1163.
[40] 人类干细胞衰老机理研究获重要成果[EB/OL]. 2015-05-05. http://news.sciencenet.cn/htmlpaper/201555930066936348.shtm.
[41] 综述:新型抗埃博拉病毒病靶点研究进展[EB/OL]. 2016-01-05. http://paper.sciencenet.cn/htmlpaper/20161512263291138344.shtm.
[42《] 自然》:十大科学事件[EB/OL]. 2015-12-31. http://news.sciencenet.cn/submore.aspx?id=2474&subid=2479.
[43] Henao-Restrepo A M, Longini I M, Egger M, et al. Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: Inter-im results from the Guinea ring vaccination cluster-randomised trial[J]. The Lancet, 2015, 386(9996): 857-866.
[44] Tong Y, Shi W, Liu D, et al. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone[J]. Nature, 2015, 524(7563): 93-96.
[45] 援非医疗团队揭示埃博拉病毒演化[EB/OL]. 2015-06-11. http://news.sciencenet.cn/htmlpaper/20156119305947036420.shtm.
[46] 2015年度艾滋病领域突破性研究进展[EB/OL]. 2015-12-01. http://www.bioon.com/3g/id/6675270/.
[47] Gres A T, Kirby K A, KewalRamani V N, et al. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability[J]. Science, 2015, 349(6243): 99-103.
[48] Science:HIV衣壳蛋白惊现水结构,抗艾药物新思路[EB/OL]. 2015-07-06. http://news.bioon.com/article/6670958.html.
[49] PNAS:新型"开瓶器"分子将HIV病毒引蛇出洞[EB/OL]. 2015-05-06. http://news.bioon.com/article/6668876.html.
[50] Richard J,Veillette M, Brassard N, et al. CD4 mimetics sensitize HIV-1-infected cells to ADCC[J]. PNAS, 2015, 112(20): E2697-E2694.
[51] NSMB:HIV疫苗开发突破性进展[EB/OL]. 2015-07-03.http://news.bioon.com/article/6670878.html.
[52] Kwon Y D, Pancera M, Acharya P, et al. Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env[J]. Nature Structural & Molecular Biology, 2015, 22: 522-531.
[53] Barouch D H, Alter G, Broge T, et al. Protective efficacy of adenovirus/protein vaccines against SIB challenges in rhesus monkeys[J]. Science, 2015, 349 (6245): 320-324.
[54] Science:科学家有望开发出强效的HIV疫苗[EB/OL]. 2015-07-06. http://news.bioon.com/article/6670902.html.
[55] 陈万青, 郑荣寿, 张思维. 中国恶性肿瘤的动态变化[J]. 科技导报, 2014, 32(26): 65-71.
[56] 日开发出一滴血可查癌症新方法[J]. 2015-06-18. http://news.xinhuanet.com/world/2015-06/18/c_1115661751.htm.
[57] Ito H, Hasegawa K, Hasegawa Y, et al. Silver nanoscale hexagonal column chips for detecting cell-free DNA and circulating nucleosomes in cancer pa-tients[J]. Scientific Reports, 2015, doi: 10.1038/srep10455.
[58] Nature:肿瘤抑制蛋白竟驱动恶性癌症[EB/OL]. 2015-09-10. http://www.bioon.com/tm/cancer/614514.shtml.
[59] Zhu J, Sammons M A, Donahue G, et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth[J]. Nature, 2015, 525(7568): 206-211.
[60] Rozhok A I, DeGregori J. Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations[J]. PNAS, 2015, 112(29): 8914-8921.
[61] 颠覆癌症起源生活方式或是重要影响[EB/OL]. 2015-07-23. http://www.bioon.com/3g/id/6671494/.
[62] Nature研究再证明食用抗氧化剂会促进癌症转移[EB/OL]. 2015-10-20. http://news.bioon.com/article/6673710.html
[63] Piskounova E, Agathocleous M, Murphy M M, et al. Oxidative stress inhibits distant metastasis by human melanoma cells[J]. Nature, 2015, 527: 186-191.
[64] Kreite S, Vormehr M, van de Roemer N, et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer[J]. Nature, 2015, 520: 692-696.
[65] 何嫱. Nature:个性化免疫疗法新突破[EB/OL]. 2015-05-17. http://www.biodiscover.com/news/research/118919.html.
[66] Obenauf A C, Zou Y, Ji A L, et al. Therapy-induced tumoursecretomes promote resistance and tumour progression[J]. Nature, 2015, 520: 368-372.
[67] Nature:癌症抗药新发现防止肿瘤复发有新招[EB/OL]. 2015-03-30. http://www.bioon.com/3g/id/6667486/.
[68] 2015糖尿病领域"15大突破进展"[EB/OL]. 2015-12-17. http://www.biodiscover.com/news/research/124671.html.
[69] 2014世界糖尿病日:我们从未停止战斗![EB/OL]. 2014-11-14. http://www.biodiscover.com/topic/hot/305.html.
[70] 何嫱. Cell挑战传统理论,揭示糖尿病病因新机制[EB/OL]. 2015-02-23. http://www.biodiscover.com/news/research/117023.html.
[71] Perry R J, Camporez J G, Kursawe R, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes[J]. Cell, 160(4): 745-758.
[72] 何嫱. 华人学者Nature:治疗糖尿病从免疫下手[EB/OL]. 2015-12-21. http://www.bioon.com/trends/news/616423.shtml.
[73] Bapat S P, Suh J M, Fang S, et al. Depletion of fat-resident Treg cells prevents age-associated insulin resistance[J]. Nature, 2015, 528(7580): 137-141.
[74] Stem Cell Reports:干细胞移植可治疗II型糖尿病[EB/OL]. 2015-03-22. http://news.bioon.com/article/6667222.html.
[75] Bruin J E, Saber N, Braun N, et al. Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs[J]. Stem Cell Reports, 2015, 4(4): 605-620.
[76] 王英. PNAS:取代胰岛素注射的智能贴片[EB/OL]. 2015-06-24. http://www.biodiscover.com/news/research/119927.html.
[77] Yu J, Zhang Y, Ye Y, et al. Microneedle-array patches loaded with hypoxia-sensitive vesicles provide fast glucose-responsive insulin delivery[J]. PNAS, 2015, 112(27): 8260-8265.
[78] Chou D H, Webber M J, Tang B C, et al. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates[J]. PNAS, 2015, 112(8): 2401-2406.
[79] PNAS:科学家发明"智能胰岛素",仅在血糖升高时奏效[EB/OL]. 2015-02-11. http://www.biodiscover.com/news/research/117112.html.
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