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贵金属纳米材料用于生物成像研究进展

  • 董夏薇 ,
  • 王雪梅
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  • 东南大学生物科学与医学工程学院, 南京 210094
董夏薇,博士研究生,研究方向为贵金属纳米材料生物成像,电子信箱:dongxwseu@foxmail.com

收稿日期: 2015-04-14

  修回日期: 2015-05-24

  网络出版日期: 2016-02-04

Recent progress of biological imaging based on noble nanomaterials

  • DONG Xiawei ,
  • WANG Xuemei
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  • School of Biological Sciences & Medical Engineering, Southeast University, Nanjing 210094, China

Received date: 2015-04-14

  Revised date: 2015-05-24

  Online published: 2016-02-04

摘要

贵金属纳米材料在光稳定性、光信号强度、生物兼容性等方面具有其他材料无法比拟的优势,已成功应用于各科学研究领域,尤其是在生命科学与生物医学研究等方面具有广阔的应用前景。本文简介贵金属纳米材料在荧光成像、拉曼成像、暗场成像的成像原理及优缺点,综述贵金属纳米材料在生物成像方面的最新研究进展。随着纳米合成技术的快速发展及检测手段的提高,贵金属纳米材料将会从基础的科学研究领域更全面地走向实际应用。而单分子光谱和光学显微成像技术取得了长足的进步,很有可能带给生物成像表征手段一次全新的革命。

本文引用格式

董夏薇 , 王雪梅 . 贵金属纳米材料用于生物成像研究进展[J]. 科技导报, 2016 , 34(2) : 81 -85 . DOI: 10.3981/j.issn.1000-7857.2016.2.012

Abstract

Noble metal nanomaterials, with the unique characteristics including light stability, strong optical signal, good bio-compatibility and so on, have incomparable advantages over other materials. They have been successfully utilized in various scientific and living areas, with broad application prospects in the area of life science and biological medicine, attracting more and more attention all over the world. This article simply summarizes the advantages and disadvantages of fluorescence imaging, Raman imaging, and the imaging principle of dark field imaging. The dark field imaging detecting scattered light of nanomaterials can eliminate effectively the background interference of sample, which has a lot of incomparable advantages. We review the latest research progress and prospect in biological imaging of noble metal nanomaterials. With the rapid development of nanometer composite technology and the improvement of detection means, noble metal nanomaterials will be brought from fundamental scientific research into practical application. And single molecular spectroscopy and optical microscopic imaging technology has made great progress, which is likely to bring new revolution in biological imaging characterization.

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