专题论文

罗氏公司血管内皮生长因子抗体技术专利分析

  • 张弛 ,
  • 张颖慧
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  • 1. 国家知识产权局专利局医药生物发明审查部, 北京 100088;
    2. 国家知识产权局专利局审查业务管理部, 北京 100088
张颖慧(共同第一作者),硕士研究生,研究方向为民商法学,电子信箱:zhangyinghui@sipo.gov.cn

收稿日期: 2016-05-17

  修回日期: 2016-05-23

  网络出版日期: 2016-06-29

Analysis of VEGF antibody technology patents of roche

  • ZHANG Chi ,
  • ZHANG Yinghui
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  • 1. Pharmacy and Biotech Examination Department, The Patent Office, State Intellectual Property Office of the P R C, Beijing 100088, China;
    2. Patent Examination Administration Departmeng, The Patent Office, State Intellectual Property Office of the P R C, Beijing 100088, China

Received date: 2016-05-17

  Revised date: 2016-05-23

  Online published: 2016-06-29

摘要

检索了罗氏公司血管内皮生长因子(vascular endothelial growth factor,VEGF)抗体相关专利申请情况,分析了贝伐珠单抗和兰尼单抗的技术研发路线、罗氏公司VEGF抗体相关在华专利布局情况,对其未来技术研发趋势和方向进行了预测。

本文引用格式

张弛 , 张颖慧 . 罗氏公司血管内皮生长因子抗体技术专利分析[J]. 科技导报, 2016 , 34(11) : 48 -52 . DOI: 10.3981/j.issn.1000-7857.2016.11.008

Abstract

This paper analyzes the technical development route of bevacizumab and ranibizumab based on the vascular endothelial growth factor (VEGF) antibody related patent applications of Roche. The layout in China of the VEGF related patents of Roche is also analyzed. Based on the above analyses, the future trends and directions of the technical research and development of VEGF antibody technology are predicted.

参考文献

[1] Ferrara N, Hillan K J, Gerber H P, et al.Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer[J].Nature Re-views Drug Discovery, 2004, 3(5): 391-400.
[2] Steinbrook R.The price of sight-ranibizumab, bevacizumab, and the treatment of macular degeneration[J].New England Journal of Medi-cine, 2006, 355(14): 1409-1412.
[3] 吴炜霖, 仲人前.人源化抗体的演进发展及应用现状[J].现代免疫学.2009, 29(4):337-340.Wu Weilin, Zhong Renqian.Development and application of humanized antibody[J].Current Immunology.2009, 29(4):337-340.
[4] Aiello L P, Avery R L, Arrigg P G, et al.Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other reti-nal disorders[J].New England Journal of Medicine, 1994, 331(22): 1480-1487.
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