研究论文

磁感应热疗恶性肿瘤技术研究进展

  • 张丽敏 ,
  • 余小刚 ,
  • 贾凯云 ,
  • 吴承伟 ,
  • 张伟 ,
  • 陈震 ,
  • Ravi Silva
展开
  • 1. 大连理工大学工程力学系, 大连 116024;
    2. 英国萨里大学先进技术研究院, 吉尔福德GU2 7XH
张丽敏,硕士研究生,研究方向为磁感应热疗中温度场的数值模拟,电子信箱:zhanglimin@mail.dlut.edu.cn。

收稿日期: 2016-06-27

  修回日期: 2017-02-17

  网络出版日期: 2017-05-25

基金资助

辽宁省自然科学基金项目(2015020198);国家自然科学基金项目(11572080)

Advance of magnetic induction hyperthermia for malignant tumor

  • ZHANG Limin ,
  • YU Xiaogang ,
  • JIA Kaiyun ,
  • WU Chengwei ,
  • ZHANG Wei ,
  • CHEN Zhen ,
  • SILVA Ravi
Expand
  • 1. Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, China;
    2. Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK

Received date: 2016-06-27

  Revised date: 2017-02-17

  Online published: 2017-05-25

摘要

磁感应热疗恶性肿瘤是一种基于交变磁场辐照磁介质并通过磁感应产热杀死肿瘤病变组织的新兴技术。20世纪60年代,磁感应热疗技术兴起,围绕提高热疗效果、开发兼具多重疗效的磁性介质和优化温度场分布,开展了大量研究工作,取得了显著效果。本文总结了铁磁热籽、磁流体、磁性脂质体、磁性微晶玻璃、磁性骨水泥等的实验研究与临床应用近期进展,指出进一步提高疗效、优化治疗区热场分布中存在的问题。

本文引用格式

张丽敏 , 余小刚 , 贾凯云 , 吴承伟 , 张伟 , 陈震 , Ravi Silva . 磁感应热疗恶性肿瘤技术研究进展[J]. 科技导报, 2017 , 35(10) : 44 -51 . DOI: 10.3981/j.issn.1000-7857.2017.10.006

Abstract

The magnetic induction hyperthermia for malignant tumor is a kind of new techniques where the heat is generated to kill the tumor lesion tissues through the magnetic media by the application of alternating magnetic fields. Since the development of the inductive heat treatment in the 1960s, many attempts were made to improve the effect of the heat treatment, to develop magnetic mediums with multimodality function and to optimize the temperature field distribution, for achieving numerous excellent results. This paper reviews the experimental studies and clinical applications of several magnetic materials, such as the ferromagnetic thermal seed, the magnetic liquid, the magnetic liposomes, the magnetic glass ceramic and the magnetic bone cement. In the meantime, the challenges in improving the efficiency of therapy and optimizing the heat field are also discussed.

参考文献

[1] 丁香园肿瘤. 全球癌症统计:一年1410万发病820万死亡[EB/OL]. 2015-04-17[2016-06-30]. http://oncol.dxy.cn/article/103894. Lilac Garden Tumor. Figures:Cancer claims 8,200,000 lives out of 14, 100,000 people who suffer from it each year globally[EB/OL]. 2015-04-17[2016-06-30]. http://oncol.dxy.cn/article/103894.
[2] 搜狐新闻. 癌症已成为我国死亡第一大原因, 死亡人数占全球癌症死亡人数四分之一[EB/OL]. 2016-01-06[2016-06-30]. http://mt.sohu.com/20160106/n433676194.shtml. Sohu News. Cancer has become the main culprit in people's death in China in which people dying of cancer accounts for a quarter of global cancer death toll[EB/OL]. 2016-01-06[2016-06-30]. http://mt.sohu.com/20160106/n433676194.shtml.
[3] Gilchrist R K, Medal R, Shorey W D, et al. Selective inductive heating of lymph nodes[J]. Annals of Surgery, 1957, 146(4):596-606.
[4] 王旭飞, 王晓文, 赵凌云, 等. 磁感应治疗研究和临床试验[J]. 科技导报, 2010, 28(16):97-105. Wang Xufei, Wang Xiaowen, Zhao Lingyun, et al. Magnetic induction hyperthermia treatme-nts by using multiple magnetic materials[J]. Sci-ence & Technology Review, 2010, 28(16):97-105.
[5] Ouyang W W, Gao F P, Wang L F, et al. Thermoseed hyperthermia treatment of mammary orthotopic transplantation tumors in rats and im-pact on immune function[J]. Oncology Reports, 2010, 24(4):973-982.
[6] Xia Q S, Liu X, Xu B, et al. Feasibility study of high-temperature ther-moseed inductive[J]. Oncology Reports, 2011, 25:953-962.
[7] Wang H, Zhang L, Shi Y R, et al. Abscopal antitumor immune effects of magnet-mediated hyperthermia at a high therapeutic temperature on Walker-256 carcinosarcomas in rats[J]. Oncology Letters, 2014, 7:764-770.
[8] Liu J Y, Zhao L Y, Wang Y Y, et al. Magnetic stent hyperthermia for esophageal cancer:An in vitro investigation in the ECA-109 cell line[J]. Oncology Reports, 2012, 27(3):791-797.
[9] Liu J Y, Li N, Li L, et al. Local hyperthermia for esophageal cancer in a rabbit tumor model:Magnetic stent hyperthermia versus magnetic flu-id hyperthermia[J]. Oncology Letters, 2013, 6:1550-1558.
[10] Pennes H H. Analysis of tissue and arterial blood temperatures in the resting human forearm[J]. Journal of Applied Physiology, 1948, 1(2):93-122.
[11] 蔡东阳, 曹欣荣, 卓子寒, 等. 磁感应热疗植入热籽产热功率分析与实验验证[J]. 清华大学学报(自然科学版), 2012, 52(12):1741-1745. Cai Dongyang, Cao Xinrong, Zhuo Zihan, et al. Analysis and experi-mental verification of the heat generation by an implanted thermoseed in magnetic induction hyperthermia[J]. Journal of Tsinghua University (Science and Technology), 2012, 52(12):1741-1745.
[12] 卓子寒, 王婕, 翟伟明, 等. 热籽介导磁感应热疗稳态温度场仿真[J]. 清华大学学报(自然科学版), 2014, 54(5):638-642. Zhuo Zihan, Wang Jie, Zhai Weiming, et al. Numerical simulations of steady-state temperature distributions during thermoseed mediated magnetic induction hyperthermia[J]. Journal of Tsinghua University (Science and Technology), 2014, 54(5):638-642.
[13] 孟萃, 唐劲天, 程建平, 等. 铁磁热籽热疗中温度场稳态分布的三维数值研究[C]//第十一届中国体视学与图像分析学术年会论文集. 宁波:中国体视学学会, 2006:505-509. Meng Cui, Tang Jintian, Cheng Jianping, et al. Three-dimensional simulation of the temperature research for ferromagnetic hyperthermia[C]//The 11th China stereology and image analysis of academic confer-ence proceedings. Ningbo:Chinese Society for Stereology, 2006:505-509.
[14] Chato J C. Fundamentals of bioheat transfer[M]. Berlin:Springer-Ver-lag Berlin Heidelberg, 1989:9-61.
[15] Hilger I, Hiergeist R, Hergt R, et al. Thermal ablation of tumors using magnetic nanoparticles an in vivo feasibility study[J]. Investigative Ra-diology, 2002, 37(10):580-586.
[16] Johannsen M, Thiesen B, Gneveckow U, et al. Thermotherapy using magnetic nanoparticles combined with external radiation in an ortho-topic rat model of prostate cancer[J]. Prostate, 2006, 66(1):97-104.
[17] 徐云钊, 奚庆华, 张玉泉. 磁性纳米顺铂微球联合磁流体热疗对卵巢癌skov-3细胞增殖、凋亡及侵袭的影响[J]. 山东医药, 2013, 53(28):13-16. Xu Yunzhao, Xi Qinghua, Zhang Yuquan. Effects of magnetic nanocisplatin microspheres combined with magnetic fluid hyperthermia on the proliferation, apoptosis and invasion of skov-3 cell line of ovarian cancer[J]. Shandong Medical Journal, 2013, 53(28):13-16.
[18] Kossatz S, Grandke J, Couleaud P, et al. Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery[J]. Breast Cancer Research, 2015, 66:1-17.
[19] 赵成桂, 袁晨燕, 吴国球, 等. p[5HRE]AFPp-p53/PEI-Fe3O4磁性纳米颗粒联合磁流体热疗对肝癌细胞的抑制作用[J]. 中国肿瘤生物治疗杂志, 2016, 23(1):44-51. Zhao Chenggui, Yuan Chenyan, Wu Guoqiu, et al. p[5HRE]AFPpp53/PEI-Fe3O4 magnetic nanoparticle combined with magnetic fluid hyperthermia inhibit hepatoma cells[J]. Chinese Journal of Cancer Bio-therapy, 2016, 23(1):44-51.
[20] 王晓朋, 傅相平, 李安民, 等. 顺磁性纳米微粒的磁靶向微血管栓塞研究[J]. 中国微侵袭神经外科杂志, 2014, 19(6):274-276. Wang Xiaopeng, Fu Xiangping, Li Anmin, et al. Magnetic targeted mi-crovascular embolization by paramagnetic nanoparticles[J]. Chinese Journal of Minimally Invasive Neurosurgery, 2014, 19(6):274-276.
[21] 孙宏亮, 许林锋, 唐劲天, 等. 兔VX2肝癌模型纳米磁微粒栓塞热疗初步研究[J]. 中华临床医师杂志, 2014, 8(18):3328-3334. Sun Hongliang, Xu Linfeng, Tang Jintian, et al. Hyperthermia after na-no magnetic particles embolization rabbit VX2 rabbit liver tumor mod-el[J]. Chinese Journal of Clinicians, 2014, 8(18):3328-3334.
[22] Kong G, Dewhirst M W. Review hyperthermia and liposomes[J]. Inter-national Journal of Hyperthermia, 1999, 15(5):345-370.
[23] 陈万瑛, 陈玉, 杨蕊, 等. 磁性隐形阿霉素脂质体的制备及其对SKOV-3细胞影响初步研究[J]. 中国实验诊断学, 2014, 18(6):880-883. Chen Wanying, Chen Yu, Yang Rui, et al. The preparation of doxoru-bicin-loaded Fe3O4 magnetic nanoparticles modified with PEG and the effect of SKOV-3[J]. Chinese Journal of Laboratory Diagnosis, 2014, 18(6):880-883.
[24] He Y N, Zhang L H, Zhu D W, et al. Design of multifunctional mag-netic iron oxide nanoparticles/mitoxantrone-loaded liposomes for both magnetic resonance imaging and targeted cancer therapy[J]. Interna-tional Journal of Nanomedicine, 2014, 9:4055-4066.
[25] Chen Y J, Chen Y, Xiao D, et al. Low-dose chemotherapy of hepato-cellular carcinoma through triggered-release from bilayer-decorated magnetoliposomes[J]. Colloids and Surfaces B:Biointerfaces, 2014, 116:452-458.
[26] Spera R, Petralito S, Liberti M, et al. Controlled release from magneto-liposomes aqueous suspensions exposed to a low intensity magnetic field[J]. Bioelectromagnetics, 2014, 35(4):309-312.
[27] Kulshrestha P, Gogoi M, Bahadur D, et al. In vitro application of pacli-taxel loaded magnetoliposomes for combined chemotherapy and hyper-thermia[J]. Colloids and Surfaces B:Biointerfaces, 2012, 96:1-7.
[28] Upadhyay D, Scalia S, Vogel R, et al. Magnetised thermo responsive lipid vehicles for targeted and controlled lung drug delivery[J]. Phar-maceutical Research, 2012, 29:2456-2467.
[29] 刘建安, 张梅梅, 刘常富, 等. 共沉淀-熔融法制备铁磁性微晶玻璃及其表征[J]. 山西大学学报(自然科学版), 2011, 34(1):85-89. Liu Jianan, Zhang Meimei, Liu Changfu, et al. Preparation and charac-terization of ferri-magnetic glass-ceramics by coprecipitation-melt-ing method[J]. Journal of Shanxi University(Science and Technology), 2011, 34(1):85-89.
[30] Lee Y K, Lee S B, Kim Y U, et al. Effect of ferrite thermoseeds on de-struction of carcinoma cells under alternating magnetic field[J]. Jour-nal of Materials Science, 2003, 38(20):4221-4233.
[31] Alcaide M, Ramı'rez-Santilla'n C, Feito M J, et al. In vitro evaluation of glass-glass ceramic thermoseed-induced threehyperthermia on hu-man osteosarcoma cell line[J]. Journal of Biomedical Materials, 2012, 100A:64-71.
[32] Bretcanu O, Miola M, Bianchi C L, et al. In vitro biocompatibility of a ferrimagnetic glass-ceramic for hyperthermia application[J]. Materials Science & Engineering C, 2016, doi:10.1016/j.msec.2016.12.105.
[33] Danewalia S S, Singh K. Magnetic and bioactive properties of MnO2/Fe2O3 modified Na2O-CaO-P2O5-SiO2 glasses and nanocrystalline glass-ceramics[J]. Ceramics International, 2016, 42(10):11858-11865.
[34] Ikenaga M, Ohura K, Yamamuro T, et al. Localized hyperthermic treat-ment of experimental bone tumors with ferromagnetic ceramics[J]. Jour-nal of Orthopaedic Research, 1993, 11(6):849-855.
[35] Matsumine A, Kusuzaki K, Matsubara T, et al. Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alter-nating electromagnetic field[J]. Clinical & experimental metastasis, 2007, 24(3):191-200.
[36] 王晓文, 胡研文, 李利亚, 等. 应用于肿瘤磁感应热疗技术的磷酸钙磁性骨水泥介质的研究[J]. 科技导报, 2014, 32(30):40-44. Wang Xiaowen, Hu Yanwen, Li Liya, et al. Novel magnetic bone ce-ment for tumor magnetic hyperthermia[J]. Science & Technology Re-view, 2014, 32(30):40-44.
[37] Drosos G I, Babourda E, Magnissalis E A, et al. Mechanical character-ization of bone graft substitute ceramic cements[J]. Injury, 2012, 43:266-271.
[38] Kawashita M, Kawamura K, Li Z. PMMA-based bone cements contain-ing magnetite particles for the hyperthermia of cancer[J]. Acta Bioma-terialia, 2010, 6:3187-3192.
[39] Tang Z H, Wang X W, Pan L. Preparation and characterization of PM-MA-based cements containing magnetic nanoparticles for the magnet-ic hyperthermia[J]. Advanced Materials Research, 2013, 647:155-159.
[40] Bruno M, Miola M, Bretcanu O, et al. Composite bone cements loaded with a bioactive and ferri-magnetic glass-ceramic. Part I:Morphologi-cal, mechanical and calorimetric characterization[J]. Journal of Bio-medical Materials, 2014, 29(2):254-267.
[41] Verné E, Bruno M, Miola M, et al. Composite bone cements loaded with a bioactive and ferrimagnetic glass-ceramic:Leaching, bioactivi-ty and cytocompatibility[J]. Materials Science and Engineering:C, 2015, 53:95-103.
[42] Deger S, Taymoorian K, Boehmer D, et al. Thermoradiotherapy using interstitial self-regulating thermoseeds:An intermediate analysis of a phase Ⅱ trial[J]. European Urology, 2004, 45(5):574-580.
[43] Tucker R D. Use of interstitial temperature self-regulating thermal rods in the treatment of prostate cancer[J]. Journal of Endourology, 2004, 17(8):601-607.
[44] Akiyama S, Kawasaki S, Kodera Y, et al. A new method of thermochemotherapy using a stent for patients with esophageal cancer[J]. Sur-gery Today, 2006, 36(1):19-24.
[45] 曾益新. 磁感应热疗技术为中国创造的希望和契机[J]. 科技导报, 2010, 28(19):3. Zeng Yixin. The technique of magnetic induction hyperthermia-A hope and opportunity for innovative meditech in China[J]. Science & Technology Review, 2010, 28(19):3.
[46] 王宇瀛, 赵凌云, 王晓文, 等. 磁感应热疗治疗肿瘤研究进展和临床试验[J]. 科技导报, 2010, 28(20):101-107. Wang yuying, Zhao Linyun, Wang Xiaowen, et al. Research progress and clinical trials of magnetic induction hyperthermia for cancer treat-ment[J]. Science & Technology Review, 2010, 28(20):101-107.
[47] 师颖瑞, 刘珈, 杨锫, 等. 磁感应热疗联合放疗治疗颈部淋巴结复发的临床观察[J]. 现代生物医学进展, 2014, 14(1):132-135. Shi Yingrui, Liu Jia, Yang Pei, et al. Clinical observation on the mag-netic induction therapy combined with radiotherapy in the treatment of recurrent cervical lymph nodes[J]. Progress in Modern Biomedicine, 2014, 14(1):132-135.
[48] Johannsen M, Gneveckow U, Eckelt L, et al. Clinical hyperthermia of prostate cancer using magnetic nanoparticles:Presentation of a new in-terstitial technique[J]. International Journal of Hyperthermia, 2005, 21(7):637-647.
[49] Maier-Hauff K, Rothe R, Scholz R, et al. Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiothera-py:Results of a feasibility study on patients with glioblastoma multi-forme[J]. Journal of Neuro-Oncology, 2007, 81(1):53-60.
[50] Matsumine A, Takegami K, Asanuma K, et al. A novel hyperthermia treatment for bone metastases using magnetic materials[J]. Internation-al Journal of Clinical Oncology, 2011, 16:101-108.
文章导航

/