专题论文

国内外实验动物模型概览

  • 张连峰 ,
  • 崔韶
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  • 中国医学科学院医学实验动物研究所, 北京协和医学院比较医学中心;卫生部人类疾病比较医学重点实验室, 北京 100021
张连峰,教授,研究方向为基因工程和疾病动物,电子信箱:zhanglf@cnilas.org

收稿日期: 2017-10-11

  修回日期: 2017-11-20

  网络出版日期: 2017-12-29

An overview of laboratory animal models at home and abroad

  • ZHANG Lianfeng ,
  • CUI Shao
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  • Key Laboratory of Human Diseases Comparative Medicine, National Health and Family Planning Commission of PRC, Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China

Received date: 2017-10-11

  Revised date: 2017-11-20

  Online published: 2017-12-29

摘要

实验动物主要分为3类,即常规实验动物,自发突变实验动物和基因工程实验动物。实验动物模型对生命科学、医学等相关学科的发展具有重要的支撑作用。中国实验动物科学起步较晚,但随着国家科研经费投入的增加,中国逐步形成了自己的研发体系和实验动物资源,在特定领域有超过美日的趋势。本文概括介绍了国内外常见实验动物模型,旨在为促进中国实验动物学科的发展提供参考。

本文引用格式

张连峰 , 崔韶 . 国内外实验动物模型概览[J]. 科技导报, 2017 , 35(24) : 27 -31 . DOI: 10.3981/j.issn.1000-7857.2017.24.002

Abstract

The laboratory animals mainly involve three categories, namely, the conventional laboratory animals, the spontaneous mutation laboratory animals and the genetic engineering laboratory animals. The laboratory animal models play an important role in the development of life sciences, medical sciences and other related disciplines. The laboratory animal science in China started relatively late, but with the increase of the national funding, China has gradually developed its own research and development system and laboratory animal resources, and is catching up with the United States and Japan in specific fields. This paper reviews the commonly-used laboratory animal models at home and abroad, in order to provide a reference for the development of the laboratory animal science in China.

参考文献

[1] International Mouse Strain Resources(IMSR)[EB/OL].[2017-10-11]. http://www.informatics.jax.org/imsr.
[2] 徐平. 实验动物资源开发、保存和共享利用[J]. 中国比较医学杂志, 2011, 21(10/11):48-56. Xu Ping. Development, conservation and sharing of laboratory animal re-sources[J]. Chinese Journal of Comparative Medicine, 2011, 21(10/11):48-56.
[3] 岳秉飞. 实验动物资源开发、引进、共享、供应[J]. 中国比较医学杂志, 2011, 21(10/11):45-47. Yue Bingfei. Development, introduction, sharing and supply of laborato-ry animal resource[J]. Chinese Journal of Comparative Medicine, 2011, 21(10/11):45-47.
[4] The Jackson Laboratory(TJL)[EB/OL].[2017-10-11]. http://jaxmice.jax.org/query.
[5] 张连峰. 我国常用实验动物资源的现状及对未来发展的思考[J]. 中国比较医学杂志, 2011, 21(10):39-44. Zhang Lianfeng. Thoughts on the status of common laboratory animal re-sources in China and the future development[J]. Chinese Journal of Comparative Medicine, 2011, 21(10):39-44.
[6] Zhang F, Wen Y, Guo X. CRISPR/Cas9 for genome editing:progress, implications and challenges[J]. Human Molecular Genetics, 2014, 23(R1):R40-R46.
[7] Ma Y, Zhang X, Shen B, et al. Generating rats with conditional alleles using CRISPR/Cas9[J]. Cell Research, 2014, 24(1):122-125.
[8] Center for Animal Resources and Development (CARD)[EB/OL].[2017-10-11]. http://cardb.cc.kumamoto-u.ac.jp/transgenic/strains.jsp.
[9] 邓巍, 许黎黎, 鲍琳琳, 等. 雪貂感染H7N9禽流感病毒动物模型的建立[J]. 中国比较医学杂志, 2014, 24(1):68-71. Deng Wei, Xu Lili, Bao Linlin, et al. The ferret models for studying the novel avian-origin human influenza A (H7N9) virus[J]. Chinese Journal of Comparative Medicine, 2014, 24(1):68-71.
[10] Shibata R, Kawamura M, Sakai H, et al. Generation of a chimeric hu-man and simian immunodeficiency virus infectious to monkey periph-eral blood mononuclear cells[J]. Journal of Virology, 1991, 65(7):3514-3520.
[11] Li J T, Halloran M, Lord C I, et al. Persistent infection of macaques with simian-human immunodeficiency viruses[J]. Journal of Virology, 1995, 69(11):7061-7067.
[12] Reimann K A, Li J T, Veazey R, et al. A chimeric simian/human im-munodeficiency virus expressing a primary patient human immunodefi-ciency virus type 1 isolate env causes an AIDS-like disease after in vivo passage in rhesus monkeys[J]. Journal of Virology, 1996, 70(10):6922-6928.
[13] Luciw P A, Pratt-Lowe E, Shaw K E, et al. Persistent infection of rhe-sus macaques with T-cell-line-tropic and macrophage-tropic clones of simian/human immunodeficiency viruses (SHIV)[J]. PNAS, 1995, 92(16):7490-7494.
[14] Iannacone M, Guidotti L G. Mouse models of hepatitis B virus patho-genesis[J]. Cold Spring Harbor Perspectives in Medicine, 2015, 5(11):a021477.
[15] Jiang P, Dickson DW. Parkinson's disease:experimental models and reality[J]. Acta Neuropathologica, 2017, doi:10.1007/S00401-017-1788-5..
[16] Liu Z, Li X, Zhang J T, et al. Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2[J]. Nature. 2016, 530(7588):98-102.
[17] Ito R, Takahashi T, Katano I, et al. Current advances in humanized mouse models[J]. Cellular & Molecular Immunology, 2012, 9(3):208-214.
[18] Walsh N C, Kenney L L, Jangalwe S, et al. Humanized mouse models of clinical disease[J]. Annual Review of Phytopathology, 2017, 12:187-215.
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