专题论文

危险化学物质的微流控合成与制备技术

  • 沈瑞琪 ,
  • 朱朋 ,
  • 叶迎华 ,
  • 夏焕明 ,
  • 赵双飞 ,
  • 陈聪 ,
  • 杨用
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  • 1. 南京理工大学化工学院, 南京 210094;
    2. 南京理工大学机械工程学院, 南京 210094
沈瑞琪,教授,研究方向为含能材料、火工品技术、空间推进技术、微系统技术以及激光与物质相互作用,电子信箱:rqshen@njust.edu.cn

收稿日期: 2018-07-01

  修回日期: 2018-08-03

  网络出版日期: 2018-08-29

Microflow synthesis and preparation of hazard chemical materials

  • SHEN Ruiqi ,
  • ZHU Peng ,
  • YE Yinghua ,
  • XIA Huanming ,
  • ZHAO Shuangfei ,
  • CHEN Cong ,
  • YANG Yong
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  • 1. School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;
    2. School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

Received date: 2018-07-01

  Revised date: 2018-08-03

  Online published: 2018-08-29

摘要

含能化合物属于一类易燃易爆的危险化学物质,极易受到机械、热和静电等刺激而发生爆炸。传统的含能化合物合成、分离、提纯、细化和包覆等工艺采用本质安全性低的间断式反应釜工艺,缺点是安全性低和线上爆炸物留存量大。微流控反应器具有大面积/体积比和小尺寸微通道,能够在爆轰临界直径下合成,而且线上留存爆炸物很少,为本质安全型。本文对比了连续相微流控、嵌段流微流控技术在化学合成上的技术优势,得出嵌段流微流控解决了晶体产物堵塞微反应通道的难题,提高了反应物的混合效率,是高敏感性含能化合物合成和制备最有前景的创新技术。

本文引用格式

沈瑞琪 , 朱朋 , 叶迎华 , 夏焕明 , 赵双飞 , 陈聪 , 杨用 . 危险化学物质的微流控合成与制备技术[J]. 科技导报, 2018 , 36(16) : 46 -52 . DOI: 10.3981/j.issn.1000-7857.2018.16.005

Abstract

Energetic materials are flammable and explosive hazard chemical materials which might explode with an slight excitation, such as the mechanical force, the heat and the static electricity. The conventional processes of synthesis, separation, purification, refining and coating for energetic materials use the internal stirred vessel technology, with a low safety and with large scale explosives kept in line. The microchannel reactor is an essential security technology, because of high ratio of surface/volume and small microchannel, in which the size of the microchannel can be designed in smaller size than the detonation critical diameter of explosives, with a small amount of explosives in line. The continuous phase micro-flow technology is widely used in synthesis and analysis of chemical materials, but the microchannel is easily blocked by solid products. The micro-segmented flow treatment is easier than that of the continuous phase flow. The innovated microsegmented flow technology is specifically suitable for the synthesis of high sensitivity hazard compounds, because of its capabilities in block-free and high efficiency mixing.

参考文献

[1] 林柄承, 秦建华. 图解微流控芯片实验室[M]. 北京:科学出版社, 2008. Lin Bingcheng, Qin Jianhua. Illustration of lab on a microflow chip[M]. Beijing:Science Press, 2008.
[2] Ugaz V M. PCR in integrated microfluidic systems[M]//Integrated Biochips for DNA Analysis. New York:Springer, 2007:90-106.
[3] Manage D P, Morrissey Y C, Stickel A J, et al. On-chip PCR amplification of genomic and viral templates in unprocessed whole blood[J]. Microfluidics & Nanofluidics, 2011, 10(3):697-702.
[4] Wirth T. Microreactors in organic synthesis and catalysis[M]. Germany:Wiley-VCH Verlag, 2008.
[5] KöHler J M, Kirner T, Wagner J, et al. Nanoparticle reactions on chip[J]. Nato Science, 2004, 152:39-50.
[6] Köhler J M, Cahill B P. Micro-segmented flow:Applications in chemistry and biology[M]. New York:Springer, 2014.
[7] Zhang J S, Wang K, Zhang C Y, et al. Safety evaluating of Beckmann rearrangement of cyclohexanone oxime in microreactors using inherently safer design concept[J]. Chemical Engineering & Processing Process Intensification, 2016, 110:44-51.
[8] Fei Y, Sun B, Zhang F, et al. Inherently safer reactors and procedures to prevent reaction runaway[J]. Chinese Journal of Chemical Engineering, 2018, 26:1252-1283.
[9] Rahman M T, Wirth T. Safe use of hazardous chemicals in flow[J]. Topics in Heterocyclic Chemistry, 201856:343-374.
[10] Singh R, Lee H J, Singh A K, et al. Recent advances for serial processes of hazardous chemicals in fully integrated microfluidic systems[J]. Korean Journal of Chemical Engineering, 2016, 33(8):2253-2267.
[11] 吴腾芳. 爆炸物识别图册[M]. 北京:国防工业出版社, 2007. Wu Tengfang. Explosives recognition atlas[M]. Beijing:National Defense Industry Press, 2007.
[12] 黄寅生. 炸药理论[M]. 北京:兵器工业出版社, 2009:125. Huang Yinsheng. Explosive theory[M]. Beijing:Ordnance Industry Publishing House, 2009:125.
[13] Liu Y, Jiang X. Why microfluidics? Merits and trends in chemical synthesis[J]. Lab on a Chip, 2017, 17(23):3960-3978.
[14] Su Y F, Kim H, Kovenklioglu S, et al. Continuous nanoparticle production by microfluidic-based emulsion, mixing and crystallization[J]. Journal of Solid State Chemistry, 2007, 180(9):2625-2629.
[15] Misuk V, Mai A, Zhao Y, et al. Active mixing inside double emulsion segments in continuous flow[J]. Journal of Flow Chemistry, 2015, 5(2):101-109.
[16] Li S, Roy A, Lichtenberg H, et al. Local structure of ZnO micro flowers and nanoparticles obtained by micro-segmented flow synthesis[J]. Chemphyschem, 2012, 13(6):1557.
[17] Budden M, Schneider S, Groß G A, et al. Microfluidic encoding:Generation of arbitrary droplet sequences by electrical switching in microchannels[J]. Sensors & Actuators A Physical, 2013, 189(189):288-297.
[18] Köhler J M, März A, Popp J, et al. Polyacrylamid/silver composite particles produced via microfluidic photopolymerization for single particle-based SERS microsensorics[J]. Analytical Chemistry, 2013, 85(1):313.
[19] Chang Z, Serra C A, Bouquey M, et al. Multiscale materials from microcontinuous-flow synthesis:ZnO and Au nanoparticle-filled uniform and homogeneous polymer microbeads[J]. Nanotechnology, 2009, 21(1):015605.
[20] Li S, Gross G A, Günther P M, et al. Hydrothermal micro continuous-flow synthesis of spherical, cylinder-, star-and flower-like ZnO microparticles[J]. Chemical Engineering Journal, 2011, 167(2/3):681-687.
[21] Li S, Roy A, Lichtenberg H, et al. Local Structure of ZnO micro flowers and nanoparticles obtained by micro-segmented flow synthesis[J]. Chemphyschem, 2012, 13(6):1557-1561.
[22] Hafermann L, Köhler J M. Small gold nanoparticles formed by rapid photochemical flow-through synthesis using microfluid segment technique[J]. Journal of Nanoparticle Research, 2015, 17(2):1-8.
[23] Knauer A, Thete A, Li S, et al. Au/Ag/Au double shell nanoparticles with narrow size distribution obtained by continuous micro segmented flow synthesis[J]. Chemical Engineering Journal, 2011, 166(3):1164-1169.
[24] Odetade D, Vladisavljevic G T. Microfluidic fabrication of hydrocortisone nanocrystals coated with polymeric stabilisers[J]. Micromachines, 2016, 7(12):236.
[25] Jongen N, Donnet M, Bowen P, et al. Development of a Continuous segmented flow tubular reactor and the "scale-out" concept-in search of perfect powders[J]. Chemical Engineering & Technology, 2010, 26(3):303-305.
[26] Chen D L, Gerdts C J, Ismagilov R F. Using microfluidics to observe the effect of mixing on nucleation of protein crystals[J]. Journal of the American Chemical Society, 2005, 127(27):9672-9673.
[27] Li L, Mustafi D, Fu Q, et al. Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103(51):19243.
[28] Duraiswamy S, Khan S A. Dual-stage continuous-flow seedless microfluidic synthesis of anisotropic gold nanocrystals[J]. Particle & Particle Systems Characterization, 2014, 31(4):429-432.
[29] Mashaghi S, Abbaspourrad A, Weitz D A, et al. Droplet microfluidics:A tool for biology, chemistry and nanotechnology[J]. Trac Trends in Analytical Chemistry, 2016, 82:118-125.
[30] Köhler J M, Li S, Knauer A. Why is micro segmented flow particularly promising for the synthesis of nanomaterials?[J]. Chemical Engineering & Technology, 2013, 36(6):887-899.
[31] Inoue T, Ohtaki K, Murakami S, et al. Direct synthesis of hydrogen peroxide based on microreactor technology[J]. Fuel Processing Technology, 2013, 108:8-11.
[32] Paunovic V, Ordomsky V, D'Angelo M F N, et al. Direct synthesis of hydrogen peroxide over Au-Pd catalyst in a wallcoated microchannel[J]. Journal of Catalysis, 2014, 309(309):325-332.
[33] Roberge D M, Noti C, Irle E, et al. Control of hazardous processes in flow:Synthesis of 2-nitroethanol[J]. Journal of Flow Chemistry, 2013, 4(1):26-34.
[34] Zuckerman N B, Shusteff M, Pagoria P F, et al. Microreactor flow synthesis of the secondary high explosive 2,6-Diamino-3, 5-dinitropyrazine-1-oxide (LLM-105)[J]. Journal of Flow Chemistry, 2015, 5(3):178-182.
[35] Delville M M E, Nieuwland P J, Janssen P, et al. Continuous flow azide formation:Optimization and scale-up[J]. Chemical Engineering Journal, 2011, 167(2/3):556-559.
[36] 刘换敏, 李兆乾, 王彦君, 等. 微流控技术制备球形发射药及其表征[J]. 含能材料, 2017, 25(9):717-721. Liu Huanmin, Li Zhaoqian, Wang Yanjun, et al. Preparation and characterization of spherical propellant by microfluidic technology[J]. Chinese Journal of Energetic Materials, 2017, 25(9):717-721.
[37] 房玉强. 基于微流控芯片的微混合技术研究[D]. 南京:南京理工大学, 2012. Fang Yuqiang. Micro mixing technology based on microfluidic chip[D]. Nanjing:Nanjing University of Science and Technology, 2012.
[38] Fang Y, Ye Y, Shen R, et al. Mixing enhancement by simple periodic geometric features in microchannels[J]. Chemical Engineering Journal, 2012, 187(2):306-310.
[39] 朱朋, 沈瑞琪, 叶迎华, 等. 嵌段流合成三硝基间苯二酚铅[C]//第十六届中国科协年会论文集. 北京:中国科学技术协会, 2014:1-5. Zhu Peng, Shen Ruiqi, Ye Yinghua, et al. Synthesis of three nitro resorcinol lead by block flow[C]//Proceeding of the 16th Annual Meeting of China Association for Science and Technology, 2014:1-5.
[40] Zhou N, Zhu P, Rong Y, et al. Microfluidic synthesis of sizecontrolled and morphologically homogeneous lead trinitroresorcinate produced by segmented flow[J]. Propellants Explosives Pyrotechnics, 2016, 41(5):899-905.
[41] 朱莹. 嵌段流合成三硝基间苯二酚铅技术研究[D]. 南京:南京理工大学, 2014. Zhu Ying. Study on synthesis of trinitroresorcinol lead by block flow[D]. Nanjing:Nanjing University of Science and Technology, 2012.
[42] 周楠. 典型硝基酚类起爆药的嵌段流合成及结晶过程研究[D]. 南京:南京理工大学. 2016. Zhou Nan. Study on block flow synthesis and crystallization process of typical nitrophenol initiatives[D]. Nanjing:Nanjing University of Science and Technology, 2016.
[43] Zhao S, Yan F, Zhu P, et al. Micro-segmented flow technology applied for synthesis and shape control of lead styphnate micro-particles[J]. Propellants Explosives Pyrotechnics, 2017, 43(3):286-293.
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