专题:康复医学的时代发展与中国策略

益生菌补充剂与人体免疫调节功能

  • 陈俊飞 ,
  • 陈健豪 ,
  • 曹佩江
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  • 1. 江苏省体育科学研究所,南京 210033
    2. 北京体育大学运动人体科学学院,北京 100084
陈俊飞,副研究员,研究方向为运动营养学,电子信箱:chenjunfei188@163.com;陈健豪(共同第一作者),硕士研究生,研究方向为运动生物化学,电子信箱:chenjianhao@bsu.edu.cn

收稿日期: 2023-03-31

  修回日期: 2023-06-06

  网络出版日期: 2023-12-21

基金资助

江苏省体育局重大体育科研课题(ST201103);江苏省体育科学研究所自主项目(BM-2023-01)

A review of immunomodulatory function of probiotic supplements on human beings

  • CHEN Junfei ,
  • CHEN Jianhao ,
  • CAO Peijiang
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  • 1. Jiangsu Research Institute of Sports Science,Nanjing 210033, China
    2. Department of Sport and Science, Beijing Sport University, Beijing 100084, China

Received date: 2023-03-31

  Revised date: 2023-06-06

  Online published: 2023-12-21

摘要

综述了益生菌补充剂对人体免疫系统的功能影响、分子生物学机制和对疾病的调节作用;益生菌不但是构成肠道局部免疫的重要环节,还可对其他系统发挥双向免疫调节作用;益生菌补充剂可激活固有免疫系统,提高吞噬细胞、自然杀伤细胞等固有免疫细胞的活性,发挥抗感染、抗肿瘤作用,可预防和治疗多种原因引起的消化道、呼吸道感染,提高人体的抗肿瘤免疫功能;益生菌补充剂还可通过激活调节性T细胞,负向调节特异性免疫系统,对食物不耐受、哮喘等过敏性疾病及溃疡性结肠炎和克罗恩病等自身免疫性疾病发挥辅助治疗的作用。

本文引用格式

陈俊飞 , 陈健豪 , 曹佩江 . 益生菌补充剂与人体免疫调节功能[J]. 科技导报, 2023 , 41(23) : 14 -19 . DOI: 10.3981/j.issn.1000-7857.2023.23.002

Abstract

This article reviews the functional effects of probiotic supplements on human immune system, the molecular biological mechanisms, and the regulatory effects on relative diseases. Probiotics not only constitute an important part of the local immune system of the intestine but also play a two-way immune regulation role in other systems. probiotic supplements can activate the innate immune system of the human body, improving the activity of phagocyte, natural killer cell and other innate immune cells, which can correct intestinal flora imbalance, prevent digestive tract infection and inflammation caused by virus infection, tumor chemotherapy and radiotherapy, improve the body's immunity to influenza and other upper respiratory tract infections, as well as improve the body's anti-tumor immunity; Probiotic supplements can also negatively regulate the specific immune system through activating regulatory T cells, which plays a certain supportive therapeutic role in treating allergic diseases such as food intolerance and asthma, as well as autoimmune diseases such as ulcerative colitis and Krohn's disease.

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