超声心动图在重度肺动脉高压大鼠右心结构与功能评估中的应用

陈豫钦; 熊缘慧; 邝美丹; 王健

doi:10.3981/j.issn.1000-7857.2024.12.01772

科技导报 >

2025 , Vol. 43 >Issue 8: 80 - 87

DOI: https://doi.org/10.3981/j.issn.1000-7857.2024.12.01772

研究论文

超声心动图在重度肺动脉高压大鼠右心结构与功能评估中的应用

陈豫钦 ,
熊缘慧 ,
邝美丹 ,
王健 ^,*

展开

呼吸疾病全国重点实验室, 广州呼吸健康研究院, 广州医科大学附属第一医院/国家呼吸医学中心, 广州 510120

王健（通信作者），教授，研究方向为肺动脉高压发病机制，电子信箱: jianwang@gzhmu.edu.cn

陈豫钦，副研究员，研究方向为肺动脉高压发病机制与药物研发，电子信箱: yqchen@gzhmu.edu.cn

熊缘慧（共同第一作者），硕士研究生，研究方向为肺动脉高压发病机制，电子信箱: xiongyuanhui@stu.gzhmu.edu.cn

收稿日期: 2024-12-17

网络出版日期: 2025-06-05

基金资助

国家自然科学基金面上项目(82170069)

广东省基础与应用基础研究基金自然科学基金面上项目(2024A1515011208)

广州市科技计划项目2025年度市校（院）企联合资助项目(2025A03J4478)

版权

收起

Application of echocardiography in the assessment of right heart structure and function in rats with pulmonary hypertension

Yuqin CHEN ,
Yuanhui XIONG ,
Meidan KUANG ,
Jian WANG ^,*

Expand

State Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

Received date: 2024-12-17

Online published: 2025-06-05

Copyright

Fold

摘要

利用小动物超声建立稳定、可靠的无创评价肺动脉高压大鼠右心结构和功能评价的方法，将雄性SD大鼠随机分为对照组和模型组，模型组采用颈部皮下注射血管内皮细胞生长因子受体抑制剂SU5416（20 mg/kg体重）后置于10%氧浓度低氧箱中饲养3周后转至常氧环境饲养3周，构建重度肺动脉高压大鼠模型。对照组置于正常环境进行饲养。造模6周后对动物进行麻醉后，进行心脏超声测量及右心导管术进行血流动力学相关指标采集，并对大鼠心脏超声指标进行均一性和重测信度分析，与大鼠右心室收缩压进行相关性分析，评价其对肺动脉高压大鼠的诊断价值。结果发现通过小动物心脏超声建立的肺动脉高压大鼠右心结构与功能评价指标具有较好的均一性及重测信度。舒张末期右室游离壁厚度、收缩末期右室游离壁厚度、三尖瓣环收缩期位移、肺动脉血流加速时间/射血时间和肺动脉血流加速时间与右心导管测得右心室收缩压具有较好的相关性（P < 0.001）及较高的诊断价值。因此，小动物超声是一种无创、稳定、重复性良好的肺动脉高压大鼠右心结构和功能评价方法，可用于该模型疾病严重程度的评估。

关键词： 超声心动图; 肺动脉高压; 右心功能

本文引用格式

陈豫钦 , 熊缘慧 , 邝美丹 , 王健 . 超声心动图在重度肺动脉高压大鼠右心结构与功能评估中的应用[J]. 科技导报, 2025 , 43(8) : 80 -87 . DOI: 10.3981/j.issn.1000-7857.2024.12.01772

参考文献

原文顺序 | 文献年度倒序 | 文中引用次数倒序

1	Weatherald J , Hemnes A R , Maron B A , et al. Phenotypes in pulmonary hypertension[J]. The European Respiratory Journal, 2024, 64 (3): 2301633. DOI

2	Hoeper M M , Humbert M , Souza R , et al. A global view of pulmonary hypertension[J]. The Lancet Respiratory Medicine, 2016, 4 (4): 306- 322. DOI

3	汪瑶, 张平洋. 超声无创评价肺动脉高压患者右心室功能的研究新进展[J]. 心血管病学进展, 2024, 45 (7): 588- 592.

4	Venet M , Malik A , Gold S , et al. Impact of right ventricular pressure overload on myocardial stiffness assessed by natural wave imaging[J]. JACC: Cardiovascular Imaging, 2025, 18 (2): 211- 225. DOI

5	Zaidi A , Knight D S , Augustine D X , et al. Echocardiographic assessment of the right heart in adults: A practical guideline from the British Society of Echocardiography[J]. Echo Research and Practice, 2020, 7 (1): G19- G41. DOI

6	郭丽敏, 武晓峰, 张淑莹, 等. 超声心动图评估野百合碱诱导的大鼠肺动脉高压[J]. 中华超声影像学杂志, 2019, 28 (7): 629- 636.

7	Zhu Z K , Godana D , Li A L , et al. Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension[J]. Pulmonary Circulation, 2019, 9 (2): 1- 9.

8	Cheng H W , Fisch S , Cheng S S , et al. Assessment of right ventricular structure and function in mouse model of pulmonary artery constriction by transthoracic echocardiography[J]. Journal of Visualized Experiments, 2014 (84): e51041.

9	Wang Y , Tian W , Xiu C H , et al. Urantide improves the structure and function of right ventricle as determined by echocardiography in monocrotaline-induced pulmonary hypertension rat model[J]. Clinical Rheumatology, 2019, 38 (1): 29- 35. DOI

10	Lambert M , Boet A , Rucker-Martin C , et al. Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension[J]. Cardiovascular Research, 2018, 114 (6): 880- 893. DOI

11	Humbert M , Kovacs G , Hoeper M M , et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension[J]. European Heart Journal, 2022, 43 (38): 3618- 3731. DOI

12	Kadoglou N P E , Khattab E , Velidakis N , et al. The role of echocardiography in the diagnosis and prognosis of pulmonary hypertension[J]. Journal of Personalized Medicine, 2024, 14 (5): 474. DOI

13	Hulot J S , Ishikawa K , Hajjar R J . Gene therapy for the treatment of heart failure: Promise postponed[J]. European Heart Journal, 2016, 37 (21): 1651- 1658. DOI

14	俞春芳, 李冰冰. 多普勒超声评估肺高压大鼠肺动脉压力准确性的比较研究[J]. 临床超声医学杂志, 2018, 20 (7): 20180727.

Rudski

L G

, Lai

W W

, Afilalo

, et al. Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American society of echocardiography endorsed by the European association of echocardiography, a registered branch of the European society of cardiology, and the Canadian society of echocardiography[J]. Journal of the American Society of Echocardiography, 2010, 23 (7): 685- 713.

DOI

16	Parasuraman S , Walker S , Loudon B L , et al. Assessment of pulmonary artery pressure by echocardiography: A comprehensive review[J]. International Journal of Cardiology Heart & Vasculature, 2016, 12: 45- 51.

17	Bossone E , D'Andrea A , D'Alto M , et al. Echocardiography in pulmonary arterial hypertension: From diagnosis to prognosis[J]. Journal of the American Society of Echocardiography: Official Publication of the American Society of Echocardiography, 2013, 26 (1): 1- 14. DOI

18	Maron M S , Hauser T H , Dubrow E , et al. Right ventricular involvement in hypertrophic cardiomyopathy[J]. The American Journal of Cardiology, 2007, 100 (8): 1293- 1298. DOI

19	中华医学会超声医学分会超声心动图学组. 中国成年人超声心动图检查测量指南[J]. 中华超声影像学杂志, 2016, 25 (8): 645- 666.

20	中华医学会超声医学分会超声心动图学组. 超声心动图评估心脏收缩和舒张功能临床应用指南[J]. Chinese Journal of Ultrasonography, 2020, 29 (6): 461- 477.

21	Zakaria D , Sachdeva R , Gossett J M , et al. Tricuspid annular plane systolic excursion is reduced in infants with pulmonary hypertension[J]. Echocardiography, 2015, 32 (5): 834- 838.

22	Peyrou J , Parsaï C , Chauvel C , et al. Echocardiographic assessment of right ventricular systolic function in a population of unselected patients before cardiac surgery: A multiparametric approach is necessary[J]. Archives of Cardiovascular Diseases, 2014, 107 (10): 529- 539.

Options

文章导航

摘要

本文引用格式

参考文献

联系我们

访问统计

模态框（Modal）标题

摘要

本文引用格式

参考文献

联系我们

访问统计