S-(+)2, 2-二甲基环丙烷甲酰胺是合成医药和农药的重要中间体,其合成方法主要分为化学合成法和生物催化法.综述了国内外2, 2-二甲基环丙烷甲酰胺的合成及拆分方法,并对各种合成方法进行分析对比,其中生物催化合成技术因具有高选择性、高催化效率和环境友好等优点而日益受到重视.生物催化合成法克服了化学合成工艺的缺陷,符合原子经济和可持续发展,具有广阔的发展前景.

S-(+)-2,2-dimethylcyclopropane carboxamide is an important intermediate for the synthetic of medicine and pesticides, there are many synthetic methods. Up-to-date information on various synthesis methods is collected and summarized from all over the world, and the advantages and disadvantages of various synthesis methods and split methods are briefly illustrated. Based on the most recently research progresses, the asymmetric synthesis of chiral catalyst is expensive, the yield is low, optical purity and cost is hard to achieve satisfactory results. However, biocatalysis synthesis technology possesses the advantages of high selectivity, high catalytic efficiency, and without pollution. Comparing with the various synthesis methods, biological catalytic synthesis method overcomes the defects caused by the chemical synthesis process, conforms to the atom economy and sustainable development. Therefore, the method is receiving more and more attention. In the further, biocatalysis is a leading research direction.