Effect of Abnormal Savda Munziq on Morphological Structure of Hepatic Tissue in Hepatocirrhosis Phase of Hepatocarcinoma Carrying Abnormal Savda Model
ABDUZAYIR Abliz1, UPUR Halmurat2, TURSUN Yusup2, KURBAN Abdukadir1, BAKRI Iskandar3
1. College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China;2. Department of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China;3. College of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830011, China
Abstract：This paper discusses the effect and possible mechanism of abnormal savda munziq on the morphological structure of hepatic tissue in hepatocirrhosis phase of hepatocarcinoma carrying abnormal savda model. According to the theory of Uighur traditional medicine, multi-complicated induction methods were adopted to establish the hepatocirrhosis phase of hepatocarcinoma carrying abnormal savda disease rat model, three other drug groups were given three different dosages (1.5, 3.0, 6.0 g/kg) of abnormal savda munziq during the whole procedure, and the pathological and ultrastructural changes of the liver in the 7th, 11th, 15th weeks were observed dynamically. The result shows that at the same point in time, the pathological and ultrastructural changes of the liver in the low dose group have not been improved significantly compared with that of the abnormal savda syndrome model group, while there have been significant improvements in the middle dose group and high dose group compared with the abnormal savda syndrome model group, such as reduction of connective tissue hyperplasia, reduction of interstitial infiltration of inflammatory cells, reduction of the degree of edema of liver cells, ultrastructural changes of uneven distribution of liver intracellular organelles and gradual reduction of liver glycogen and mitochondrial. These findings indicate that abnormal savda munziq can protect and recover the morphological damage on hepatic tissue in hepatocirrhosis phase of hepatocarcinoma carrying abnormal savda model.
2011, Vol. 29 
