乳香可舒筋行气，活血化瘀，是中医治疗痹症、湿阻病等多种疾病的常用药材，但乳香类药物存在诱发不良反应的风险。通过回顾性研究，将2022年1—6月于北京中医药大学附属护国寺中医医院开具含有乳香成分的中药处方作为研究对象，通过统计描述、相关性分析及多因素回归分析，旨在明确影响乳香不良反应的独立性因素。采用的指标包括处方中的乳香剂量、给药方式，患者的年龄、性别、过敏史以及记录不良反应类型等。结果共纳入108例处方，其中7例处方引发了不良反应，包括皮肤过敏6例、腹泻1例，多因素回归分析显示患者既往过敏史是影响乳香不良反应的唯一独立危险因素；说明现阶段中医临床实践使用的含有乳香的中药方剂所致的不良反应仅与既往过敏史有关，患者过敏史是合理用药、控制不良反应中需重点把握的环节。
Frankincense can relax sinew, promote flow of qi and blood circulation, and remove blood stasis. It is a commonly used medicinal material in traditional Chinese medicine for the treatment of arthralgia, dampness blocking disease and others. Frankincense drugs have the risk of inducing adverse reactions. This study used the traditional Chinese medicine prescriptions containing frankincense drugs in Huguosi traditional Chinese Medicine Hospital Affiliated to Beijing University of traditional Chinese Medicine from Jan to Mar 2022 as the research object. This retrospective study aimed to clarify the independent factors that affect the adverse reactions of frankincense through statistical description, correlation analysis and multivariate regression analysis. Indicators included dosage of frankincense in the prescription, mode of administration, as well as patient's age, gender, allergy history, adverse reactions, etc. Altogether 108 prescriptions were received, of which 7 prescriptions caused adverse reactions, including 6 skin allergies and 1 diarrhea. Multivariate regression analysis showed that the patient's allergy history was the only independent risk factor affecting the adverse reactions of frankincense drugs. It is shown that the adverse reactions of frankincense formula used in the clinical practice of traditional Chinese medicine at this stage are only related to the patient's allergy history, and which should be the focus of rational drug use and adverse reaction control.
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