[1.] Tong H F, Chan C Y, Ng S W, et al. Strychnine poisoning due to traditional chinese medicine: A case series[J]. F1000Research, 2021, 10: 924.
[2.] 解宝仙, 唐文照, 王利红, 等. 马钱子化学成分研究[J].中药材, 2016, 39(1): 86-89.
[3.] Zehra T, Sarfaraz S, Ikram R. Dose dependent anticonvulsant activity of morus nigra in strychnine induced seizures model[J]. Pakistan Journal of Pharmaceutical Sciences, 2021, 34(6): 2167-2171
[4.] Maddisetty P N P, Doss V A, Mohanasundaram S, et al. HPLC and GC-MS: Identification and quantification of strychnine and brucine in Strychnos nux-vomica leaves [J]. Pakistan Journal of Pharmaceutical Sciences, 2017, 30 (6): 2369-2373.
[5.] He L, Wang X, Wu X, et al. Asymmetric total synthesis of (+)-strychnine[J]. Organic Letters, 2019, 21(1): 252- 255.
[6.] He L, Xiong D, Ma L, et al. Ion-pair compounds of strychnine for enhancing skin permeability:Influencing the transdermal processes in vitro based on molecular simulation[J].Pharmaceuticals (Basel), 2021, 15(1): 1-12.
[7.] Downs J, Wolf C E, Williams G, et al. Negligible nux vomica: Homeopathic nux vomica remedies don't contain strychnine[J]. Toxicon, 2021, 200: 1-2.
[8.] Ding Y W, Jin L, Feng S L, et al. Core-shell magnetic zeolite imidazolate framework-8 as adsorbent for magnetic solid phase extraction of brucine and strychnine from human urine[J]. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 2021, 1173: 122702.
[9.] Hur M H, Havalad V, Clardy C. Strychnine: Old remedy, silent killer[J]. Pediatric Annals, 2019, 48(5): e205-e207.
[10.] Sniegocki T, Sell B, Posyniak A. The usefulness of MS(3) to confirm poisoning on the example of dog poisoning with strychnine[J]. Molecules, 2019, 24(20): 3765.
[11.] Hufnagel L A, Pierobon P, Kass-Simon G. Immunocytochemical localization of a putative strychnine-sensitive glycine receptor in hydra vulgaris[J]. Cell and Tissue Research, 2019, 377(2): 177-191.
[12.] Huang X, Chen H, Michelsen K, et al. Crystal structure of human glycine receptor-alpha3 bound to antagonist strychnine[J]. Nature, 2015, 526(7572): 277-280.
[13.] Roper S, Diamond J. Strychnine antagonism and glycine: A reply[J]. Nature, 1970, 225(5239): 1259.
[14.] Zlotos D P, Mohsen A M Y, Mandour Y M, et al. 11- aminostrychnine and N-(strychnine-11-yl)propionamide: Synthesis, configuration, and pharmacological evaluation at glycine receptors[J]. Journal of Natural Products, 2019, 82(8): 2332-2336.
[15.] Zlotos D P, Mandour Y M, Jensen A A. Strychnine and its mono- and dimeric analogues: A pharmaco-chemical perspective[J]. Natural Product Reports, 2022, doi: 10.1039/d1np00079a.
[16.] Qader B, Hussain I, Baron M, et al. The production and evaluation of an electrochemical sensors for strychnine and its main metabolite strychnine N-oxide for their use in biological samples[J]. Molecules, 2022, 27(6): 1826.
[17.] Bonnet O, Beniddir M A, Champy P, et al. Exploration by molecular networking of Strychnos alkaloids reveals the unexpected occurrence of strychnine in seven Strychnos species[J]. Toxicon, 2022, 215: 57-68.
[18.] Kelly L, Seifi M, Ma R, et al. Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability[J]. Neuropathology and Applied Neurobiology, 2021, 47(4): 488-505.
[19.] Odagaki Y, Kinoshita M, Toyoshima R. Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes[J]. Journal of Pharmacological Sciences, 2014, 125(2): 157-168.
[20.] 谢阳,伍淳操,杨宗发,等.马钱子药理和毒性机制的研究进展[J].华西药学杂志, 2022, 37(1): 102-107.
[21.] Chen J, Qu Y, Wang D, et al. Pharmacological evaluation of total alkaloids from nux vomica: Effect of reducing strychnine contents[J]. Molecules, 2014, 19(4): 4395-4408.
[22.] Contreras-Nunez E, Blancas-Flores G, Cruz M, et al. Participation of the IKK-alpha/beta complex in the inhibition of the TNF-alpha/NF-kappaB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes[J]. Biomed Pharmacother, 2018, 102: 120-131.
[23.] Abdallah M H, Abu Lila A S, Unissa R, et al. Preparation, characterization and evaluation of anti-inflammatory and anti-nociceptive effects of brucine-loaded nanoemulgel[J]. Colloids and Surfaces B-Biointerfaces, 2021, 205: 111868.
[24.] Wu P, Liang Q, Feng P, et al. A novel brucine gel transdermal delivery system designed for anti-inflammatory and analgesic activities[J]. International Journal of Molecular Sciences, 2017, 18(4): 757-769.
[25.] Lin J, Gao L, Lin Y, et al. Pharmacokinetics-based chronoefficacy of semen strychni and tripterygium glycoside tablet against rheumatoid arthritis[J]. Front Pharmacol, 2021, 12: 673263.
[26.] Li Y, Liu Y, Shao Y, et al. Mechanism of action of strychni semen for treating rheumatoid arthritis and methods for attenuating the toxicity[J]. Combinatorial Chemistry & High Throughput Screening, 2022, 25(4): 587-606.
[27.] Chen G X, Tong J, Liu Q P, et al. Paharmacological mechanisms of cellular immunity of overall alkali of tongbiling for the treatment of joint destruction[J]. Chinese Journal of Cellular and Molecular Immunology, 2007, 23(6): 527-530.
[28.] Tang M, Zhu W J, Yang Z C, et al. Brucine inhibits TNF-alpha-induced HFLS-RA cell proliferation by activating the JNK signaling pathway[J]. Experimental and Therapeutic Medicine, 2019, 18(1): 735-740.
[29.] Milne B, Hall S R, Sullivan M E, et al. The release of spinal prostaglandin E2 and the effect of nitric oxide synthetase inhibition during strychnine-induced allodynia[J]. Anesthesia & Analgesia, 2001, 93(3): 728-733.
[30.] Yin W, Wang T S, Yin F Z, et al. Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica[J]. Journal of Ethnopharmacology, 2003, 88(2/3): 205-214.
[31.] Patel K, Laloo D, Singh G K, et al. A review on medicinal uses, analytical techniques and pharmacological activities of Strychnos nux-vomica Linn.: A concise report [J]. Chinese Journal of Integrative Medicine, 2017, doi: 10.1007/s11655-016-2514-1.
[32.] Zhang M, Deng Y, Wang C, et al. An LC-MS/MS method for determination of bioactive components of liquorice and semen strychni in rat plasma: Application to a pharmacokinetics study[J]. Drug Testing and Analysis, 2018, 10(2): 262-271.
[33.] Frederich M, Hayette M P, Tits M, et al. Reversal of chloroquine and mefloquine resistance in plasmodium falciparum by the two monoindole alkaloids, icajine and isoretuline[J]. Planta Medica, 2001, 67(6): 523-527.
[34.] Frederich M, De Pauw M, Prosperi C, et al. Strychnogucines a and b, two new antiplasmodial bisindole alkaloids from Strychnos icaja[J]. Journal of Natural Products, 2001, 64(1): 12-16.
[35.] Philippe G, De Mol P, Zeches-Hanrot M, et al. Indolomonoterpenic alkaloids from Strychnos icaja roots[J]. Phytochemistry, 2003, 62(4): 623-629.
[36.] Jonville M C, Dive G, Angenot L, et al. Dimeric bisindole alkaloids from the stem bark of Strychnos nux-vomica L.[J]. Phytochemistry, 2013, 87: 157-163.
[37.] Tchinda A T, Jansen O, Nyemb J N, et al. Strychnobaillonine, an unsymmetrical bisindole alkaloid with an unprecedented skeleton from Strychnos icaja roots[J]. Journal of Natural Products, 2014, 77(4): 1078-1082.
[38.] Beaufay C, Ledoux A, Jansen O, et al. In vivo antimalarial and antitrypanosomal activity of strychnogucine b, a bisindole alkaloid from Strychnos icaja[J]. Planta Medica, 2018, 84(12/13): 881-885.
[39.] Li P, Zhang M, Ma W J, et al. Effects of brucine on vascular endothelial growth factor expression and microvessel density in a nude mouse model of bone metastasis due to breast cancer[J]. Chinese Journal of Integrative Medicine, 2012, 18(8): 605-609.
[40.] Ma Y, Li Z, Wang Y, et al. Brucine induces the apoptosis of U266 multiple myeloma cells by phosphorylation of c-Jun[J]. Molecular Medicine Reports, 2013, 7(2): 481-484.
[41.] Ruijun W, Wenbin M, Yumin W, et al. Inhibition of glioblastoma cell growth in vitro and in vivo by brucine, a component of Chinese medicine[J]. Oncology Research, 2014, 22(5/6): 275-281.
[42.] Saraswati S, Agrawal S S. Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo[J]. Cancer Letters, 2013, 332(1): 83- 93.
[43.] 赵引利. 马钱子碱及其制剂研究进展[J]. 肿瘤研究与临床, 2017, 29(11): 784-788.
[44.] Zhang Y, Brekken R A. Direct and indirect regulation of the tumor immune microenvironment by VEGF[J]. Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society, 2022, 111(6): 1269-1286.
[45.] Annese T, Tamma R, Ribatti D. Rnascope for VEGF-A detection in human tumor bioptic specimens[J]. Methods in Molecular Biology, 2022, 2475: 143-155.
[46.] Chen J, Liu J, Xu B, et al. Ethoxy-erianin phosphate and afatinib synergistically inhibit liver tumor growth and angiogenesis via regulating VEGF and EGFR signaling pathways[J]. Toxicology and Applied Pharmacology 2022, 438: 115911.
[47.] Saraswati S, Alhaider A A, Agrawal S S. Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats[J]. Chemico-Biological Interactions, 2013, 206(2): 214-221.
[48.] Luo W J, Wang X L, Zheng L, et al. Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway[J]. Journal of Cellular and Molecular Medicine, 2013, 17(10): 1316-1324.
[49.] Agrawal S S, Saraswati S, Mathur R, et al. Cytotoxic and antitumor effects of brucine on ehrlich ascites tumor and human cancer cell line[J]. Life Sciences, 2011, 89(5/6): 147-158.
[50.] Hu K F, Kong X Y, Zhong M C, et al. Brucine inhibits bone metastasis of breast cancer cells by suppressing Jagged1/Notch1 signaling pathways[J]. Chinese Journal of Integrative Medicine, 2017, 23(2): 110-116.
[51.] Lee S M, Kwon J I, Choi Y H, et al. Induction of G2/M arrest and apoptosis by water extract of strychni semen in human gastric carcinoma ags cells[J]. Phytotherapy Research, 2008, 22(6): 752-758.
[52.] Rao P S, Ramanadham M, Prasad M N V. Anti-proliferative and cytotoxic effects of Strychnos nux-vomica root extract on human multiple myeloma cell line-RPMI 8226[J]. Food and Chemical Toxicology, 2009, 47(2): 283-288.
[53.] Shi X, Zhu M, Kang Y, et al. Wnt/beta-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells[J]. Phytomedicine, 2018, 46: 85-92.
[54.] Zheng L, Wang X, Luo W, et al. Brucine, an effective natural compound derived from nux-vomica, induces G1 phase arrest and apoptosis in LoVo cells[J]. Food and Chemical Toxicology, 2013, 58: 332-339.
[55.] Li S, Wang X P. In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine[J]. International Journal of Nanomedicine, 2017, 12: 5797-5804.
[56.] He J Y, Wu L, Wang J C, et al. Anti-tumor effect of brucine-loaded chitosan nanoparticles in vitro[J]. Acta Pharmaceutica Sinica, 2016, 51(4): 650-656.
[57.] Shu G, Mi X, Cai J, et al. Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: The role of hypoxia inducible factor 1 pathway[J]. Toxicology Letters, 2013, 222(2): 91-101.
[58.] Deng X, Yin F, Lu X, et al. The apoptotic effect of brucine from the seed of Strychnos nux-vomica on human hepatoma cells is mediated via Bcl-2 and Ca2+ involved mitochondrial pathway[J]. Toxicological Sciences: An Official Journal of the Society of Toxicology, 2006, 91(1): 59-69.
[59.] Deng X K, Yin W, Li W D, et al. The anti-tumor effects of alkaloids from the seeds of Strychnos nux-vomica on HepG2 cells and its possible mechanism[J]. Journal of Ethnopharmacology, 2006, 106(2): 179-186.
[60.] Rao P S, Prasad M N. Strychnos nux-vomica root extract induces apoptosis in the human multiple myeloma cell line-U266b1[J]. Cell Biochemistry And Biophysics, 2013, 66(3): 443-450.
[61.] Chen J, He C Q, Lin A H, et al. Thermosensitive liposomes with higher phase transition temperature for targeted drug delivery to tumor[J]. International Journal of Pharmaceutics, 2014, 475(1/2): 408-415.
[62.] Qin J M, Yin P H, Li Q, et al. Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma[J]. International Journal of Nanomedicine, 2012, 7: 369-379.
[63.] Yin W, Deng X K, Yin F Z, et al. The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells[J]. Food and Chemical Toxicology, 2007, 45(9): 1700-1708.