以DEP患者作为研究对象,利用脑涨落图仪(EFG)的客观检查方法及DEP现代医学评分系统,评价解郁合欢汤+五行音乐疗法的中医综合治疗方式对DEP的疗效。指标包括EFG检测大脑神经递质相对功率值、汉密尔顿抑郁量表(HAMD)以及蒙哥马利抑郁评定量表(MADRS)。EFG结果显示,患者治疗后脑内γ-氨基丁酸的相对功率值较治疗前显著降低(P<0.001),去甲肾上腺素(P<0.001)、多巴胺相对功率值(P<0.001)较治疗前显著提高,患者治疗后的 HAMD(P<0.001)、MADRS(P<0.001)较治疗前显著降低。说明中医综合疗法对 DEP的疗效确切,可通过对大脑神经递质的调节作用而发挥抗抑郁疗效。
Depression (DEP) has become the second greatest threat to human health. In order to evaluate the efficacy of traditional Chinese medicine comprehensive therapy (Jieyu Hehuan Decoction + five element music therapy) on DEP, DEP patients were enrolled and the objective examination of encephaloflocturograph (EFG) and the DEP scoring system were adopted in this study. The indexes include the relative power of brain neurotransmitter based on EFG, Hamilton Depression Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS). The results show that the relative power of γ -Aminobutyric acid decreases (P<0.001) while the relative power of dopamine (P<0.001) and norepinephrine (P<0.001) increase after the therapy, as well as the HAMD (P<0.001) and MADRS (P<0.001). It suggests that the traditional Chinese medicine comprehensive therapy has the proved efficacy on DEP, which produces the anti-DEP effect through the regulation of brain neurotransmitters.
[1] Huang Y Q, Wang Y, Liu Z R, et al. Prevalence of mental disorders in China: A cross-sectional epidemiological study[J]. The Lancet Psychiatry, 2019, 6(3): 211-224.
[2] Phillips M R, Zhang J X, Shi Q C, et al. Prevalence treatment and associated disability of mental disorders in four provinces in China during 2001-05: An epidemiological survey[J]. Lancet, 2009, 373(9680): 2041-2053.
[3] 吴勉华,王新月.中医内科学[M].北京:中国中医药出版社, 2014: 351-353.
[4] Monchi O, Ji H K, Strafella A P, et al. Striatal dopamine release during performance of executive functions: A[(11) C] raclopride PET study[J]. Neuroimage, 2006, 33(3): 907-912.
[5] Huang T L, Lin C C. Advances in biomarkers of major depressive disorder[J]. Advances in Clinical Chemistry, 2015, 68: 177-204.
[6] Yao Y C, Zhao S, Zhang Y H, et al. Job-related burnout is associated with brain neurotransmitter levels in Chinese medical workers: A cross-sectional study[J]. Journal of International Medical Research, 2018, 46(8): 3226- 3235.
[7] 朱维煌,王石,刘屏,等.脑电潮汐涨落图技术在多种精神疾病中的应用及研究进展[J].世界最新医学信息文摘,2018,18(62):64-65.
[8] 郭田生.脑涨落图的技术原理及临床研究应用[J]. 国际神经病学神经外科学杂志, 2014,41(2):127-130.
[9] 费伯雄,彭荣琛,齐玲玲.医醇剩义[M].北京:中国医药科技出版社,2018:193.
[10] 林奕,张月娟,廖若夷,等.五行音乐之角调对缺血性脑卒中后肝气郁结型抑郁患者干预效果的护理观察[J].湖南中医药大学学报,2018,38(2):216-219.
[11] 中华医学会精神科分会.中国精神障碍分类与诊断标准:第3版[M].济南:山东科学技术出版社,2001:53.
[12] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[13] 张文韬,田乃佳,王俭,等.《黄帝内经》五音疗法治疗轻中度焦虑抑郁症的疗效评价[J].中国中医药现代远程教育,2018,16(23):54-56.
[14] 王帅菊.五行音乐之角调干预经前期综合征情志异常40例效果观察[J].湖南中医杂志,2021,37(6):103-105.
[15] Melzer J, Rostock M, Brignoli R, et al. Preliminary data of a HAMD-17 validated symptom scale derived from the ICD-10 to diagnose depression in outpatients[J]. Research in Complementary Medicine, 2012, 19(4): 191-196.
[16] Soron T R. Validation of Bangla Montgomery Asberg depression rating scale (MADRSB)[J]. Asian Journal of Psychiatry, 2017, 28(1): 41-46.
[17] 邢玉瑞.七情内涵及致病特点[J].中国中医基础医学杂志,2003,9(9):6-7,17.
[18] 王萌,周永学.中医郁病理论的源流与发展[J].中华中医药杂志,2022,37(4):1878-1881.
[19] 梁喆盈,雷英菊,金玲.张景岳论治郁证浅析[J].时珍国医国药,2008,19(2):493-494.
[20] 李冉,田介峰,罗学军,等.合欢花的化学成分及其药理作用的研究进展[J].天津药学,2022,34(2):66-71.
[21] 丁超,许寅,葛韵芝.当归多糖对慢性应激抑郁小鼠的行为影响及其机制研究[J].西部中医药,2021,34(6):21-27.
[22] 张超伟,张钰,苏珊,等.茯苓类药材本草学、化学成分和药理作用研究进展[J].湖北农业科学,2021,60(2):9-14,19.
[23] 陈宇鑫,赵云,王瑛,等.应激性抑郁患者认知功能与脑内神经递质变化分析[J].军事医学,2021,45(5):354-357.