科技人文

卡尔·巴里·夏普莱斯——两获诺贝尔奖的化学家

  • 陈彪 ,
  • 王燕 ,
  • 张艳 ,
  • 李婷婷 ,
  • 朱玥玮 ,
  • 李功 ,
  • 吴又进
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  • 1. 中国科学技术大学科技史与科技考古系,合肥 230026
    2. 南宁市第二十六中学,南宁 530022
陈彪,副教授,研究方向为科技史、科技考古,电子信箱:chenbiao@ustc.edu.cn

收稿日期: 2023-01-18

  修回日期: 2023-02-10

  网络出版日期: 2023-04-27

基金资助

安徽省高等学校省级质量工程项目(2022szsfkc010,2022jyjxggyj031,2022jyjxggyj030,2019jyxm0014);中国科学技术大学校级教学研究项目(2022ychx10,2022ycjg14,2022xjyxm009,2018jyy13,2020kcsz062,2021ycjg12,2021kcsz035)

Karl Barry Sharpless: A chemist who was awarded his second Nobel Prize

  • CHEN Biao ,
  • WANG Yan ,
  • ZHANG Yan ,
  • LI Tingting ,
  • ZHU Yuewei ,
  • LI Gong ,
  • WU Youjin
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  • 1. Department of History of Science and Scientific Archaeology, University of Science and Technology of China, Hefei 230026, China
    2. No. 26 Senior High School of Nanning, Nanning 530022, China

Received date: 2023-01-18

  Revised date: 2023-02-10

  Online published: 2023-04-27

摘要

2022年诺贝尔化学奖授予卡罗琳·露丝·贝尔托西、摩顿·梅尔达尔和卡尔·巴里·夏普莱斯,以表彰他们“为点击化学和生物正交化学的发展”做出的贡献。这是夏普莱斯继因在不对称催化领域的成就而获得2001年诺贝尔化学奖后,再次获得该奖。概述了夏普莱斯的科研历程及其在点击化学领域的研究成就,分析了点击化学简单高效的特点。同时,夏普莱斯的研究方向从手性催化氧化反应到点击化学的转变,体现了突破自我和永不止步的科研精神,也为如何培养创新型科学家提供了启示。

本文引用格式

陈彪 , 王燕 , 张艳 , 李婷婷 , 朱玥玮 , 李功 , 吴又进 . 卡尔·巴里·夏普莱斯——两获诺贝尔奖的化学家[J]. 科技导报, 2023 , 41(3) : 89 -94 . DOI: 10.3981/j.issn.1000-7857.2023.03.010

Abstract

The Nobel Prize in Chemistry 2022 was jointly awarded to Carolyn Ruth Bertozzi, Morten Meldal and Karl Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. Sharpless has won the Nobel Prize in Chemistry for the second time since 2001. This paper reviews his scientific research and achievements in the field of click chemistry, analyzes the characteristics of click chemistry, that is, simplicity and efficiency. Meanwhile, the paper points out that his research direction changing from chiral catalytic oxidation reaction to click chemistry reflects the scientific spirit of selfbreakthrough and never-ending and the interdisciplinarity of his study also reveals the way to cultivate innovative scientists.

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