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| Prethrombotic Seate in Bronchial Asthmatic Patients with Abnormal Savda |
| TUERXUN Kelibiena1, SIMAYI Mihereguli1, WUFUE Dilinuer1, AIZEZI Renaguli2, UPUR Halmurat2 |
1. Department of Respiratory Disease, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China;
2. Faculty of Traditional Uighur Medicine, Xinjiang Medical University, Urumqi 830011, China |
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Abstract: This paper discusses the changes of CD41, CD62P, ET-1, t-PA, PAI-1, FIB, APTT, PT, and TT in asthma patients with abnormal Savda. Totally 76 asthmatic patients were syndrome typed according to the body fluid theory of Uygur medicine. Among them, there were 30 asthmatic patients with abnormal Savda and 46 asthmatic patients without abnormal Savda. A comparison study was performed with 89 normal individuals (as the healthy control group). The expression of CD62P on platelets, the level of plasma tissue plasminogen activator (t-PA) and its inhibiter (PAI-1), the level of endothelin-1 (ET-1), activated partial thromboplastin time (APTT), fibrinogen (FIB), prothrombin time (PT) and thrombin time (TT) were tested by using flow cytometer, ELASA method, radioimmunoassay method and auto coagulometer. Finally, we found the followings. Compared to the normal control group, there was no significance between the expressions of the asthma with abnormal Savda group and the asthma without abnormal Savda group (P> 0.05); For the expression of CD62P in all the three groups (P<0.05), the expression of CD62P in the asthma with abnormal Savda group was significantly higher than that of the asthma without abnormal Savda group (P<0.05); The level of serum ET-1 was significantly higher in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of ET-1 was significantly higher in the asthma with abnormal Savda group than those of the asthma without abnormal Savda group and the normal control group (P<0.01); The level of plasma t-PA was significantly lower in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of serum PAI-1 was significantly higher in both the asthma with abnormal Savda and the asthma without abnormal Savda groups (P<0.05); The level of plasma FIB was significantly higher in the asthma with abnormal Savda and asthma without abnormal Savda groups (P<0.05), the level of plasma FIB was significantly higher in the asthma with abnormal Savda group than those of the asthma without abnormal Savda group and the normal control group; The level of APTT and PT were significantly shortened in the asthma with abnormal Savda and asthma without abnormal Savda groups (P<0.05). There was no significance on TT between these three groups.
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Received: 20 May 2013
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2014, Vol. 32 
